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Allele Symbol Allele Name Allele ID |
Ppargc1atm2Brsp targeted mutation 2, Bruce M Spiegelman MGI:3693963 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• on a C57BL/6 background, mice show no change in baseline coat color relative to control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice fed a high fat diet exhibit normal heat production and oxygen consumption
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• in mice fed a high fat diet
• however, mice fed standard chow exhibit normal glucose serum levels
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• in mice fed standard chow or a high fat diet
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| N |
• mice fed a high fat diet exhibit normal food intake
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| N |
• mice fed standard chow or a high fat diet exhibit normal body weight and composition
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fasting-mediated induction of aminolevulinic acid synthase is decreased in mutants compared to wild-type
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• injection of lead chloride into fasted mice does not alter serum gamma-aminolevulinic acid (ALA) or porphobilinogen (PBG) in contrast to increased levels observed in wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice fed standard chow or a high fat diet exhibit normal insulin tolerance
• hepatic glucose output under basal and clamped conditions is normal
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• in mice fed a high fat diet
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• in mice fed a high fat diet
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• in mice fed a high fat diet
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• mice exhibit increased systemic glucose uptake and glycolysis compared with control mice
• however, glycogen synthesis is normal
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• in fed mice on standard chow
• however, fasted mice exhibit normal blood glucose levels
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• in fasted and fed mice on a high fat diet
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• in fed mice on standard chow or a high fat diet
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• in fed mice on a high fat diet
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• in mice fed a high fat diet
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| N |
• islets exhibit normal basal and glucose-stimulated insulin secretion
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• reduced cell size
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• in mice fed standard chow or a high fat diet
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• in mice fed a high fat diet
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• in mice fed standard chow or a high fat diet
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• decreased function as measured by Cox and succinate dehydrogenase activity
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• during the day and night in mice fed a high fat diet
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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