About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ceacam1tm1Rsb
targeted mutation 1, Richard S Blumberg
MGI:3693674
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ceacam1tm1Rsb/Ceacam1tm1Rsb
Tg(Lck-cre)1Cwi/0 		involves: 129 MGI:3695216


Genotype
MGI:3695216
cn1
Allelic
Composition		 Ceacam1tm1Rsb/Ceacam1tm1Rsb
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ceacam1tm1Rsb mutation (0 available); any Ceacam1 mutation (45 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:116136 )
• anti-CD3 and anti-CD28 stimulation enhances proliferation compared to wild-type
abnormal cytokine secretion ( J:116136 )
• anti-CD3 and anti-CD28 stimulation enhances cytokine production by T cells
increased interferon-gamma secretion ( J:116136 )
• Ifng secretion by T cells upon anti-CD3 and anti-CD28 stimulation is enhanced
increased interleukin-2 secretion ( J:116136 )
• IL-2 secretion by T cells upon anti-CD3 and anti-CD28 stimulation is enhanced

hematopoietic system
increased T cell proliferation ( J:116136 )
• anti-CD3 and anti-CD28 stimulation enhances proliferation compared to wild-type

cellular
increased T cell proliferation ( J:116136 )
• anti-CD3 and anti-CD28 stimulation enhances proliferation compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory