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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(PSEN1H163R)G9Btla
transgene insertion G9, Bruce Lamb
MGI:3693364
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3693489
cx2
 		Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3693490
cx3
 		Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0 		involves: 129S4/SvJae MGI:3693492
tg4
 		Tg(PSEN1H163R)G9Btla/0 involves: 129S4/SvJae MGI:3693491


Genotype
MGI:3693489
cx1
Allelic
Composition		 Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (4 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:58050 )
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months

homeostasis/metabolism
amyloid beta deposits ( J:58050 )
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months




Genotype
MGI:3693490
cx2
Allelic
Composition		 Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (4 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:58050 )
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months

homeostasis/metabolism
amyloid beta deposits ( J:58050 )
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months




Genotype
MGI:3693492
cx3
Allelic
Composition		 Tg(APPSwLon)96Btla/0
Tg(PSEN1H163R)G9Btla/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSwLon)96Btla mutation (1 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:58050 )
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged

homeostasis/metabolism
amyloid beta deposits ( J:58050 )
• double hemizygous mice show a a significant increase in Abeta1-42 amyloid peptide accumulation seen at 4 months mice compared to Tg(PSEN1H163R)G9Btla mice; levels of full-length APP are unchanged




Genotype
MGI:3693491
tg4
Allelic
Composition		 Tg(PSEN1H163R)G9Btla/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(PSEN1H163R)G9Btla mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:58050 )
• lower levels of Abeta1-42 amyloid peptide accumulate compared to double transgenic mice

homeostasis/metabolism
amyloid beta deposits ( J:58050 )
• lower levels of Abeta1-42 amyloid peptide accumulate compared to double transgenic mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:58050
Alzheimer's disease 3 DOID:0110042 OMIM:607822
 J:58050




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory