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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itga3tm1Son
targeted mutation 1, Arnaud Sonnenberg
MGI:3691084
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd151tm2Nki/Cd151tm2Nki
Itga3tm1Son/Itga3+
Krt14tm1(cre)Wbm/? 		FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm MGI:5550138
cn2
 		Itga3tm1Son/Itga3tm1Son
Tg(KRT5-cre)5132Jlj/? 		involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:3836770
cn3
 		Itga3tm1Son/Itga3tm1Son
Krt14tm1(cre)Wbm/Krt14+ 		involves: 129P2/OlaHsd * FVB/N MGI:3836769
cn4
 		Itga3tm1Son/Itga3tm1Son
Tg(NPHS2-cre)295Lbh/0 		Not Specified MGI:3691146


Genotype
MGI:5550138
cn1
Allelic
Composition		 Cd151tm2Nki/Cd151tm2Nki
Itga3tm1Son/Itga3+
Krt14tm1(cre)Wbm/?
Genetic
Background		 FVB.129P2-Cd151tm2Nki Itga3tm1Son Krt14tm1(cre)Wbm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd151tm2Nki mutation (0 available); any Cd151 mutation (34 available)
Itga3tm1Son mutation (0 available); any Itga3 mutation (52 available)
Krt14tm1(cre)Wbm mutation (0 available); any Krt14 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:205736 )
• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151tm2Nki/Cd151tm2Nki Krt14tm1(cre)Wbm mice
• however, overall benign and malignant histology is normal
decreased tumor growth/size ( J:205736 )
• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151tm2Nki/Cd151tm2Nki Krt14tm1(cre)Wbm mice

integument
decreased keratinocyte proliferation ( J:205736 )
• in papillomas of DMBA- and TPA-treated mice

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:205736 )
• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151tm2Nki/Cd151tm2Nki Krt14tm1(cre)Wbm mice
• however, overall benign and malignant histology is normal

cellular
decreased keratinocyte proliferation ( J:205736 )
• in papillomas of DMBA- and TPA-treated mice




Genotype
MGI:3836770
cn2
Allelic
Composition		 Itga3tm1Son/Itga3tm1Son
Tg(KRT5-cre)5132Jlj/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Son mutation (0 available); any Itga3 mutation (52 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
skin inflammation ( J:145988 )
• inflammation occurs frequently around 3 to 4 months of age at the ears and around the eyes

integument
skin inflammation ( J:145988 )
• inflammation occurs frequently around 3 to 4 months of age at the ears and around the eyes
alopecia ( J:145988 )
• alopecia starts at 3 to 4 months after birth and progresses with age
blistering ( J:145988 )
• microblisters occur at the dermis-epidermis junction
thick skin ( J:145988 )
• epidermis is thickened around the ears, the eyes, and at sites of microblistering




Genotype
MGI:3836769
cn3
Allelic
Composition		 Itga3tm1Son/Itga3tm1Son
Krt14tm1(cre)Wbm/Krt14+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Son mutation (0 available); any Itga3 mutation (52 available)
Krt14tm1(cre)Wbm mutation (0 available); any Krt14 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
enhanced wound healing ( J:145988 )
• wound healing of the epidermis is accelerated
• about 90% of experimental wounds are closed after one week compared to about 60% in controls
• this enhanced wound healing is due to accelerated keratinocyte migration from sides of wound and not from increased proliferation

immune system
skin inflammation ( J:145988 )
• inflammation occurs frequently around 3 to 4 months of age at the ears and around the eyes

integument
skin inflammation ( J:145988 )
• inflammation occurs frequently around 3 to 4 months of age at the ears and around the eyes
alopecia ( J:145988 )
• alopecia starts at 3- to 4- months after birth and progresses with age
blistering ( J:145988 )
• microblisters occur at the dermis-epidermis junction
thick skin ( J:145988 )
• epidermis is thickened around the ears, the eyes, and at sites of microblistering




Genotype
MGI:3691146
cn4
Allelic
Composition		 Itga3tm1Son/Itga3tm1Son
Tg(NPHS2-cre)295Lbh/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Son mutation (0 available); any Itga3 mutation (52 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Glomerular basement membrane abnormalities and foot process effacement in kidneys of mildly affected Cd151tm1Nki/Cd151tm1Nki and Itga3tm1Son/Itga3tm1Son Tg(NPHS2-cre)295Lbh/0 mice

renal/urinary system
increased urine protein level ( J:114988 )
• exhibit massive proteinuria starting within the first week of age
podocyte foot process effacement ( J:114988 )
• complete effacement of podocyte foot processes in newborns
abnormal renal glomerulus basement membrane morphology ( J:114988 )
• glomerular basement membrane (GBM) is disorganized
• 6 week old mutants show widespread lamination and protrusions of the GBM
increased renal glomerulus basement membrane thickness ( J:114988 )
• abnormally thickened GBM with protrusions throughout the glomerulus
glomerulosclerosis ( J:114988 )
• kidneys contain partially sclerosed glomeruli
dilated proximal convoluted tubule ( J:114988 )
• dilated proximal tubules contain prominent protein casts
renal cast ( J:114988 )
• dilated proximal tubules contain prominent protein casts
pale kidney ( J:114988 )
• milky, discolored kidneys

homeostasis/metabolism
edema ( J:114988 )
• develop abdominal edema at 5-6 weeks of age
increased urine protein level ( J:114988 )
• exhibit massive proteinuria starting within the first week of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory