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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igkctm1(IGKC)Mnz
targeted mutation 1, Michel C Nussenzweig
MGI:3690646
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Igkctm1(IGKC)Mnz/Igkc+
Igk-Jtm1(CD4*)Mss/Igk-J+ 		involves: 129S4/SvJae MGI:3829707
cx2
 		Igkctm1(IGKC)Mnz/Rr166tm4.1Wtg involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5475002
cx3
 		Igkctm1(IGKC)Mnz/Igkc+
Rr158tm1(Igh)Xu/Rr158+ 		Not Specified MGI:3758451


Genotype
MGI:3829707
cx1
Allelic
Composition		 Igkctm1(IGKC)Mnz/Igkc+
Igk-Jtm1(CD4*)Mss/Igk-J+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1(IGKC)Mnz mutation (2 available); any Igkc mutation (9 available)
Igk-Jtm1(CD4*)Mss mutation (0 available); any Igk-J mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin light chain V-J recombination ( J:143876 )
• mice were bred to carry the two mutant alleles in trans
• a 2:1 skew in favor of expression of the Igk-Ctm1(IGKC)Mnz allele among immature and mature B cells suggests the CD4 knock-in allele causes a recombination defect

hematopoietic system
abnormal immunoglobulin light chain V-J recombination ( J:143876 )
• mice were bred to carry the two mutant alleles in trans
• a 2:1 skew in favor of expression of the Igk-Ctm1(IGKC)Mnz allele among immature and mature B cells suggests the CD4 knock-in allele causes a recombination defect




Genotype
MGI:5475002
cx2
Allelic
Composition		 Igkctm1(IGKC)Mnz/Rr166tm4.1Wtg
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1(IGKC)Mnz mutation (2 available); any Igkc mutation (9 available)
Rr166tm4.1Wtg mutation (0 available); any Rr166 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:193015 )
• slight preferential usage of the deleted mouse allele rather than the inserted human allele
abnormal immunoglobulin level ( J:193015 )
• slight preferential usage of the deleted mouse allele rather than the inserted human allele

hematopoietic system
abnormal B cell physiology ( J:193015 )
• slight preferential usage of the deleted mouse allele rather than the inserted human allele
abnormal immunoglobulin level ( J:193015 )
• slight preferential usage of the deleted mouse allele rather than the inserted human allele




Genotype
MGI:3758451
cx3
Allelic
Composition		 Igkctm1(IGKC)Mnz/Igkc+
Rr158tm1(Igh)Xu/Rr158+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1(IGKC)Mnz mutation (2 available); any Igkc mutation (9 available)
Rr158tm1(Igh)Xu mutation (0 available); any Rr158 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system morphology ( J:124407 )
• the efficiency of rearrangement of the Igk-Eiktm1(Igh)Xu allele is lower than that of the wild-type allele
decreased B cell number ( J:124407 )
• the percent of mouse immunoglobin kappa+ B cells is reduced with the ratio of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells of about 6:1 compared to equal number of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells when the wild-type Igk allele is present instead of Igk-Eiktm1(Igh)Xu

hematopoietic system
decreased B cell number ( J:124407 )
• the percent of mouse immunoglobin kappa+ B cells is reduced with the ratio of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells of about 6:1 compared to equal number of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells when the wild-type Igk allele is present instead of Igk-Eiktm1(Igh)Xu




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory