Rr166^tm4.1Wtg
Targeted Allele Detail

Summary

• Symbol: Rr166^tm4.1Wtg
• Name: regulatory region 166; targeted mutation 4.1, William Garrard
• MGI ID: MGI:5474643
• Synonyms: Igk^deltaHS1-2, Igk^tm4.1Wtg
• Gene: Rr166 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr166^tm4.1Wtg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193015
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Two DNAse1 hypersensitive sites, termed "contracting element for recombination" or "Cer", were replaced with a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination was then used to remove the resistance cassette in mice. (J:193015)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr166 Mutation: 0 strains or lines available

References

• Original: J:193015 Xiang Y, et al., Vkappa Gene Repertoire and Locus Contraction Are Specified by Critical DNase I Hypersensitive Sites within the Vkappa-Jkappa Intervening Region. J Immunol. 2013 Feb 15;190(4):1819-26
• All: 1 reference(s)