Phenotypes associated with this allele

• Allele Symbol: Fbxo11^Mutt
• Allele Name: Mutt
• Allele ID: MGI:3690632
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxo11^Mutt/Fbxo11^Mutt	involves: BALB/c * C3H/HeN	MGI:3693676
ht2	Fbxo11^Mutt/Fbxo11^+	involves: BALB/c * C3H/HeN	MGI:3693671
ht3	Fbxo11^Jf/Fbxo11^Mutt	involves: BALB/c * C3H/HeN	MGI:3693680

Genotype
MGI:3693676

hm1

• Allelic Composition: Fbxo11^Mutt/Fbxo11^Mutt
• Genetic Background: involves: BALB/c * C3H/HeN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:114851 )

• a small proportion of homozygotes showed perinatal lethality

craniofacial

short face ( J:114851 )

• shortened face found in 84% of surviving homozygotes

cleft palate ( J:114851 )

• mild clefting of the palate in those mice showing neonatal lethality

midline facial cleft ( J:114851 )

• in some among the mice showing neonatal lethality

hearing/vestibular/ear

impaired hearing ( J:114851 )

• reduced hearing in 42% of surviving homozygotes using the 24 kHz, 90 dB SPL tone burst

• none had otitis media

digestive/alimentary system

cleft palate ( J:114851 )

• mild clefting of the palate in those mice showing neonatal lethality

growth/size/body

short face ( J:114851 )

• shortened face found in 84% of surviving homozygotes

cleft palate ( J:114851 )

• mild clefting of the palate in those mice showing neonatal lethality

midline facial cleft ( J:114851 )

• in some among the mice showing neonatal lethality

Genotype
MGI:3693671

ht2

• Allelic Composition: Fbxo11^Mutt/Fbxo11⁺
• Genetic Background: involves: BALB/c * C3H/HeN

behavior/neurological

decreased startle reflex ( J:114851 )

• a reduced startle response to tone burst of 24kHz, 90dB SPL

• no otitis media at 39-45 days old

craniofacial

short face ( J:114851 )

• a mild craniofacial abnormality, shortened face

growth/size/body

short face ( J:114851 )

• a mild craniofacial abnormality, shortened face

Genotype
MGI:3693680

ht3

• Allelic Composition: Fbxo11^Jf/Fbxo11^Mutt
• Genetic Background: involves: BALB/c * C3H/HeN

mortality/aging

neonatal lethality, incomplete penetrance ( J:114851 )

• a small proportion (12%) of compound heterozygous showed perinatal lethality similar to Fbxo11^Jf/Fbxo11^Jf or similar to Fbxo11^Mutt/Fbxo11^Mutt

hearing/vestibular/ear

impaired hearing ( J:114851 )

• reduced hearing in response to a click box similar to Fbxo11^Jf heterozygotes

increased susceptibility to otitis media ( J:114851 )

• similar to Fbxo11^Jf/Fbxo11⁺

immune system

increased susceptibility to otitis media ( J:114851 )

• similar to Fbxo11^Jf/Fbxo11⁺

craniofacial

short face ( J:114851 )

• shortened face similar to Fbxo11^Jf/Fbxo11⁺

midline facial cleft ( J:114851 )

• in some similar to Fbxo11^Jf/Fbxo11^Jf or similar to Fbxo11^Mutt/Fbxo11^Mutt

growth/size/body

short face ( J:114851 )

• shortened face similar to Fbxo11^Jf/Fbxo11⁺

midline facial cleft ( J:114851 )

• in some similar to Fbxo11^Jf/Fbxo11^Jf or similar to Fbxo11^Mutt/Fbxo11^Mutt

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:114851