Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ss18tm1Adg mutation
(0 available);
any
Ss18 mutation
(40 available)
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mortality/aging
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• Background Sensitivity: onset of embryonic lethality occurs earlier than in the mixed background as embryos show signs of resorption at E9.5, however stage when initiation of lethality occurs is not stated
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ss18tm1Adg mutation
(0 available);
any
Ss18 mutation
(40 available)
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mortality/aging
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• Background Sensitivity: lethality is initiated after E8.5 but before E9.5 and resorption is observed at E11.5 and E13.5, later than on a congenic C57BL/6 background
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growth/size/body
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• about 50% exhibit a swollen heart
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• 90% of E9.5 embryos exhibit growth retardation that varies from rudimentary embryos within the embryonic membranes to embryos lagging behind and estimated to be at E8.5
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embryo
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• exhibit little or no embryonic turning at E9.5
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• developmental arrest occurs just after gastrulation as mutants show little or no embryonic turning
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• 90% of E9.5 embryos exhibit growth retardation that varies from rudimentary embryos within the embryonic membranes to embryos lagging behind and estimated to be at E8.5
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• neural tube is only partially closed at E9.5
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• exhibit impaired placental vascularization and vascular branching
• blood vessels are either located outside the placenta or exclusively near the base where the surrounding trophoblast tissue is very compact, and never in close proximity to the maternal sinuses
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• the number of blood vessels in the prospective labyrinth is reduced
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• chorionic plate of placentas is composed of densely packed trophoblasts and does not exhibit vascularization
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• labyrinth development is disturbed
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• impaired placental development, either through incomplete chorio-allantoic fusion or through a defect in the subsequent process of vascular branching morphogenesis
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• observe the formation of an allantoic ball, indicating impaired chorioallantoic fusion
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cardiovascular system
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• about 50% exhibit dilated blood vessels in the head region
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• exhibit impaired placental vascularization and vascular branching
• blood vessels are either located outside the placenta or exclusively near the base where the surrounding trophoblast tissue is very compact, and never in close proximity to the maternal sinuses
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• the number of blood vessels in the prospective labyrinth is reduced
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• about 50% exhibit a swollen heart
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• about 50% are hemorrhagic
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nervous system
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• neural tube is only partially closed at E9.5
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homeostasis/metabolism
Allelic
Composition |
Ss18tm1Adg/Ss18+
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Genetic
Background |
involves: C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ss18tm1Adg mutation
(0 available);
any
Ss18 mutation
(40 available)
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mortality/aging
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• show an underrepresentation of heterozygotes at weaning, however stage of lethality is not specified
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growth/size/body
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• 43% of E9.5 embryos exhibit growth retardation
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embryo
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• 43% of E9.5 embryos exhibit growth retardation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ss18l1tm1Ghsh mutation
(0 available);
any
Ss18l1 mutation
(17 available)
Ss18tm1Adg mutation
(0 available);
any
Ss18 mutation
(40 available)
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mortality/aging
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• mutants are identified at E9.5 and E18.5 but not after birth, indicating perinatal lethality
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Analysis Tools