Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm2(FCMD)Ttd mutation
(0 available);
any
Fktn mutation
(44 available)
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homeostasis/metabolism
muscle
N |
• despite alpha-dystroglycan hypoglycosylation, no evidence of muscular dystrophy is observed at birth or in older mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fktntm1Ttd mutation
(0 available);
any
Fktn mutation
(44 available)
Fktntm2(FCMD)Ttd mutation
(0 available);
any
Fktn mutation
(44 available)
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homeostasis/metabolism
nervous system
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• a few mice exhibit a very small ectopic cluster of neurons migrating into the marginal zone are observed unlike in wild-type mice
• however, brain morphology is otherwise normal
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muscle
N |
• despite alpha-dystroglycan hypoglycosylation, no evidence of muscular dystrophy is observed at birth or in older mice
• even after exercise exhaustion, muscle cell membrane permeability is normal
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cellular
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• a few mice exhibit a very small ectopic cluster of neurons migrating into the marginal zone are observed unlike in wild-type mice
• however, brain morphology is otherwise normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dysfim mutation
(3 available);
any
Dysf mutation
(183 available)
Fktntm1Ttd mutation
(0 available);
any
Fktn mutation
(44 available)
Fktntm2(FCMD)Ttd mutation
(0 available);
any
Fktn mutation
(44 available)
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muscle
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• macrophage infiltration is increased in skeletal muscle compared to mice homozygous for Dysfim and heterozygous for Fktntm2(FCMD)Ttd
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• increases of connective tissue infiltrations in skeletal muscles
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• albumin-positive myofibers are increased in skeletal muscle indicating deterioration of the myofiber membrane fragility
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• at 15 weeks and 30 weeks of age, but not at 8 weeks, mutants show significantly more fibers with centrally located nuclei than do mice homozygous for Dysfim and heterozygous for Fktntm2(FCMD)Ttd, indicating more frequent cycles of muscle cell degeneration and regeneration
• the proportion of fibers with centrally located nuclei increases with age
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• at 15 and 30 weeks of age, but not at 8 weeks, mutants show more frequent cycles of muscle cell degeneration and regeneration
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• fibrotic area is increased in skeletal muscle
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• mice show further progressed and more severe dystrophic features than mice homozygous for Dysfim and heterozygous for Fktntm2(FCMD)Ttd in quadriceps, gastrocnemius, and tibialis anterior muscles
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immune system
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• macrophage infiltration is increased in skeletal muscle compared to mice homozygous for Dysfim and heterozygous for Fktntm2(FCMD)Ttd
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dysfim mutation
(3 available);
any
Dysf mutation
(183 available)
Fktntm1Ttd mutation
(0 available);
any
Fktn mutation
(44 available)
Fktntm2(FCMD)Ttd mutation
(0 available);
any
Fktn mutation
(44 available)
|
|
|
muscle
N |
• mice do not show any obvious features of muscular dystrophy
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dysfim mutation
(3 available);
any
Dysf mutation
(183 available)
Fktntm2(FCMD)Ttd mutation
(0 available);
any
Fktn mutation
(44 available)
|
|
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muscle
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• albumin-positive myofibers are only sparsely seen in skeletal muscles indicating latent membrane fragility
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• mice show mild dystrophic changes such as the presence of necrotic fibers and centrally located nuclei
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cellular