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Targeted Allele Detail
Symbol: Fktntm2(FCMD)Ttd
Name: fukutin; targeted mutation 2, Tatsushi Toda
MGI ID: MGI:3690337
Synonyms: FtknHp
Gene: Fktn  Location: Chr4:53713745-53765785 bp, + strand  Genetic Position: Chr4, 28.74 cM
Alliance: Fktntm2(FCMD)Ttd page
Germline Transmission:  Earliest citation of germline transmission: J:114512
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Fktntm2(FCMD)Ttd expresses 1 gene
Mutation detailsExon 10 was removed from the locus via Cre mediated expression following the insertion of lox71 and loxP sites. Human FCMD exon 10 cDNA from a patient with Fukuyama Congenital Muscular Dystrophy with the causative retrotransposon was inserted between the lox66 and loxP sites of the targeting construct. Transcript expression level is 5% to 10% of normal. (J:114512)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fktn Mutation:  21 strains or lines available
Original:  J:114512 Xiong H, et al., Molecular interaction between fukutin and POMGnT1 in the glycosylation pathway of alpha-dystroglycan. Biochem Biophys Res Commun. 2006 Dec 1;350(4):935-41
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory