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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Septin12+
wild type
MGI:3689366
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Septin12em1Lych/Septin12+ C57BL/6-Septin12em1Lych MGI:7327408
ht2
 		Septin12tm1.1Plk/Septin12+ chimera involves: 129/Sv * C57BL/6 MGI:3843449
ht3
 		Septin12tm3Plk/Septin12+ involves: 129 * C57BL/6 MGI:6887458


Genotype
MGI:7327408
ht1
Allelic
Composition		 Septin12em1Lych/Septin12+
Genetic
Background		 C57BL/6-Septin12em1Lych
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin12em1Lych mutation (0 available); any Septin12 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:324492 )
N
• surprisingly, heterozygous male mice show normal testis morphology and weight and are fertile, unlike the infertile heterozygous Septin12tm1.1Plk male chimeras reported in J:147965
• after intracytoplasmic sperm injection (ICSI), 69% of wild-type oocytes injected with heterozygous sperm develop to 2-cell embryos and only 8.6% develop to the blastocyst stage, indicating that sperm quality is slightly impaired only under sub-optimal in vitro conditions




Genotype
MGI:3843449
ht2
Allelic
Composition		 Septin12tm1.1Plk/Septin12+
Genetic
Background		 chimera involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin12tm1.1Plk mutation (0 available); any Septin12 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent sperm flagellum ( J:147965 )
• in some low-expressing chimeras
kinked sperm flagellum ( J:147965 )
• in 36% of sperm from low-expressing chimera and 38% of sperm from high-expressing chimeras
abnormal sperm head morphology ( J:147965 )
• disorganized mitochondria in low-expressing chimeras
abnormal acrosome morphology ( J:147965 )
• in high-expressing chimeras, the acrosome almost fails to form unlike in wild-type mice
globozoospermia ( J:147965 )
• in high-expressing chimeras
detached acrosome ( J:147965 )
• low-expressing chimeras exhibit loose and broken in germ cells unlike in wild-type mice
decreased male germ cell number ( J:147965 )
• some mice exhibit generalized loss of germ cells at all stages unlike in wild-type mice
asthenozoospermia ( J:147965 )
• reduced sperm motility
arrest of spermatogenesis ( J:147965 )
• some mice exhibit arrested spermatogenesis at the spermatid stage unlike in wild-type mice

endocrine/exocrine glands

cellular
absent sperm flagellum ( J:147965 )
• in some low-expressing chimeras
kinked sperm flagellum ( J:147965 )
• in 36% of sperm from low-expressing chimera and 38% of sperm from high-expressing chimeras
abnormal sperm head morphology ( J:147965 )
• disorganized mitochondria in low-expressing chimeras
abnormal acrosome morphology ( J:147965 )
• in high-expressing chimeras, the acrosome almost fails to form unlike in wild-type mice
globozoospermia ( J:147965 )
• in high-expressing chimeras
detached acrosome ( J:147965 )
• low-expressing chimeras exhibit loose and broken in germ cells unlike in wild-type mice
decreased male germ cell number ( J:147965 )
• some mice exhibit generalized loss of germ cells at all stages unlike in wild-type mice
asthenozoospermia ( J:147965 )
• reduced sperm motility




Genotype
MGI:6887458
ht3
Allelic
Composition		 Septin12tm3Plk/Septin12+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin12tm3Plk mutation (0 available); any Septin12 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:223228 )
N
• heterozygotes exhibit a normal testis weight-to-body weight ratio and no significant change in the number of spermatozoa isolated from the vas deferens relative to wild-type males
• no obvious morphological sperm defects are observed in the head, annulus or tail structures
asthenozoospermia ( J:223228 )
• heterozygotes show significantly reduced sperm motility relative to wild-type males

cellular
asthenozoospermia ( J:223228 )
• heterozygotes show significantly reduced sperm motility relative to wild-type males




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory