About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdx1tm1Egs
targeted mutation 1, Edouard G Stanley
MGI:3688420
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Pdx1tm1Egs/Pdx1+ involves: 129S1/Sv MGI:3695580
cx2
 		Pdx1tm1Egs/Pdx1+
Stk11tm1.1Gne/Stk11tm1.1Gne 		involves: 129S1/Sv * C57BL/6N MGI:5484546


Genotype
MGI:3695580
ht1
Allelic
Composition		 Pdx1tm1Egs/Pdx1+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1tm1Egs mutation (1 available); any Pdx1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:110137 )
• mice are phenotypically indistinguishable from wild-type and expression of the reporter faithfully reproduces the known expression pattern of Pdx1




Genotype
MGI:5484546
cx2
Allelic
Composition		 Pdx1tm1Egs/Pdx1+
Stk11tm1.1Gne/Stk11tm1.1Gne
Genetic
Background		 involves: 129S1/Sv * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1tm1Egs mutation (1 available); any Pdx1 mutation (35 available)
Stk11tm1.1Gne mutation (0 available); any Stk11 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
pancreas cyst ( J:195229 )
• dynamic and AMPK-independent cyst formation in late, but not early, stage pancreas explants treated with 1NMPP1
• pancreatic cysts induced by treatment with 1NMPP1 evolve into precancerous-like lesions without loss of cell polarity

cellular
increased cell proliferation ( J:195229 )
• increased epithelial cell proliferation accompanies pancreatic cyst formation in 1NMPP1-treated pancreatic explants

growth/size/body
pancreas cyst ( J:195229 )
• dynamic and AMPK-independent cyst formation in late, but not early, stage pancreas explants treated with 1NMPP1
• pancreatic cysts induced by treatment with 1NMPP1 evolve into precancerous-like lesions without loss of cell polarity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory