Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2ctm1Will mutation
(0 available);
any
Tfap2c mutation
(28 available)
Tfap2ctm2Will mutation
(1 available);
any
Tfap2c mutation
(28 available)
Tg(Zp3-cre)3Mrt mutation
(2 available)
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embryo
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N |
• blastocyts derived from zygotes lacking both maternal and zygotic Tcfap2c contributions make it through preimplantation development
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mortality/aging
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• a significant reduction in number of double-null embryos (5.5% vs 25% expected) compared to 3 other possible genotypic combinations results in earlier lethality than loss of either allele alone (~E7.5)
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embryo
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N |
• double-null embryos are found at ~expected frequencies (~25%) at E3.5; embryos are detected in both the morula (~75%) and blastocyst (~25%) stages, indicating that deficiency of both Tcfap2a and Tcfap2c does not affect the zygote prior to E3.5;
• other genotypic combinations are all found at similar frequencies (~25%) at E7.5, indicating that loss of any combination of 3 of 4 wild-type Tcfap2a and Tcfap2c alleles allows embryo survival to ~E7.5
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embryo
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• embryos are smaller than wild-type, with morphology similar to published reports of Tcfap2c-null embryos
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• embryos are more disorganized than wild-type, with morphology similar to published report of Tcfap2c-null embryos
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• embryos are more disorganized than wild-type, with morphology similar to published report of Tcfap2c-null embryos
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growth/size/body
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• embryos are smaller than wild-type, with morphology similar to published reports of Tcfap2c-null embryos
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Analysis Tools
