About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il4tm1(CD2)Mmrs
targeted mutation 1, Markus Mohrs
MGI:3686902
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs involves: 129 MGI:5313997
ht2
 		Il4tm1(CD2)Mmrs/Il4tm1Lky involves: 129/Sv * C57BL/6 MGI:3687996
cn3
 		Il13tm1(YFP/cre)Lky/Il13+
Il4tm1(CD2)Mmrs/Il4+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:5435903
cx4
 		Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+ 		involves: 129 * BALB/cJ * C57BL/6 MGI:5313999


Genotype
MGI:5313997
hm1
Allelic
Composition		 Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation compared with Il4tm1(CD2)Mmrs heterozygotes
decreased IgE level ( J:178986 )
• in mice infected with Nippostrongylus brasiliensis
decreased IgG1 level ( J:178986 )
• in an anti-NP response
decreased interleukin-4 secretion ( J:181313 )
• in parathymic lymph node and lung-draining mediastinal node T cells from mice injected with ovalbumin
• in T cells and basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation compared with Il4tm1(CD2)Mmrs heterozygotes

hematopoietic system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation compared with Il4tm1(CD2)Mmrs heterozygotes
decreased IgE level ( J:178986 )
• in mice infected with Nippostrongylus brasiliensis
decreased IgG1 level ( J:178986 )
• in an anti-NP response




Genotype
MGI:3687996
ht2
Allelic
Composition		 Il4tm1(CD2)Mmrs/Il4tm1Lky
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (41 available)
Il4tm1Lky mutation (3 available); any Il4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:113279 )
• mice are viable; dual-reporter mice were used for detailed profiling of Il4 mRNA and protein production in response to stimulation in culture and parasitic infection in vivo




Genotype
MGI:5435903
cn3
Allelic
Composition		 Il13tm1(YFP/cre)Lky/Il13+
Il4tm1(CD2)Mmrs/Il4+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (1046 available)
Il13tm1(YFP/cre)Lky mutation (1 available); any Il13 mutation (25 available)
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
increased susceptibility to parasitic infection ( J:178986 )
• mice exhibit reduced helminthes Nippostrongylus brasiliensis expulsion compared with control mice

hematopoietic system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis




Genotype
MGI:5313999
cx4
Allelic
Composition		 Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+
Genetic
Background		 involves: 129 * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cigs2tm1.1Anse mutation (0 available); any Cigs2 mutation (0 available)
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:181313 )
N
• following intraperitoneal injection of ovalbumin, mice exhibit normal IgG2b response compared with Il4tm1(CD2)Mmrs heterozygotes
• T cells and basophils exhibit normal Il13 production
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
decreased IgE level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased IgG1 level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased interleukin-4 secretion ( J:181313 )
• in Th2 polarized CD4+ T cells compared with Il4tm1(CD2)Mmrs heterozygotes
• in parathymic lymph node and lung-draining mediastinal node T cells from mice injected with ovalbumin
• in T cells and basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation

hematopoietic system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
decreased IgE level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased IgG1 level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory