Phenotypes associated with this allele
mortality/aging
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• mice fed a tamoxifen-containing diet show a deterioration of health and die within 3 weeks due to multiple organ failure
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Bbd mutation
(2 available);
any
Kras mutation
(76 available)
Mapk1tm1.1Hed mutation
(0 available);
any
Mapk1 mutation
(40 available)
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mortality/aging
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• 50% survival at 34.9 weeks versus 31.2 weeks in single Kras mutants following intratracheal instillation of Ad-Cre, indicating a 16% increase in survival
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neoplasm
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• mice develop non-small cell lung carcinoma following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre); tumor burden in similar to that seen in single Kras heterozygotes
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respiratory system
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• mice develop non-small cell lung carcinoma following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre); tumor burden in similar to that seen in single Kras heterozygotes
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mortality/aging
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• following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre), mutants show 50% survival at 63 weeks versus 48 weeks in single Kras mutants, a 40% increase in survival
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neoplasm
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• 6 months following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre), only a few tumors are observed; tumors that are found express normal levels of Mapk1
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1.1Hed mutation
(0 available);
any
Mapk1 mutation
(40 available)
Tg(Lck-cre)1Cwi mutation
(3 available)
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homeostasis/metabolism
immune system
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• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation
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• there is a larger decrease in CD4 T cells than CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
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• there is a decrease in CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
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hematopoietic system
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• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation
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• there is a larger decrease in CD4 T cells than CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
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• there is a decrease in CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
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