Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Flv mutation
(1 available);
any
Nlrp3 mutation
(61 available)
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immune system
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• by bone marrow derived dendritic cells in response to phenol-purified LPS with ATP and commercial LPS
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Flv mutation
(1 available);
any
Nlrp3 mutation
(61 available)
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digestive/alimentary system
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• dextran sodium sulfate (DSS)-treated mice housed with wild-type mice exhibit attenuated colitis compared with wild-type mice
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immune system
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• dextran sodium sulfate (DSS)-treated mice housed with wild-type mice exhibit attenuated colitis compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Flv mutation
(1 available);
any
Nlrp3 mutation
(61 available)
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immune system
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• do not process caspase-1 and secrete less IL1B in response to LPS and ATP treatment
• impaired secretion of IL1A, IL1B and IL18 in TLR-primed and ATP-treated cells; however secretion of TNFA, IL6, and IL12 are similar to wild-type
• absence of bacterial muramyl dipeptide-stimulated IL1B secretion
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• significant decrease in serum IL1B levels after challenge with 37.5 mg/kg of LPS
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• significant decrease in serum IL18 levels after challenge with 37.5 mg/kg of LPS
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• no difference in the degree of ear swelling between sensitized (with trinitrophenylchloride) and naive mice
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• with lower doses of LPS (18.75 and 9.38 mg/kg) mortality is delayed or reduced, respectively, compared to wild-type mice
• however with a high dose of LPS ((37.5 mg/kg) no difference in the time course of incidence of mortality is seen and the time course of macrophage cell death in response to Salmonella tymphimurium is similar to wild-type
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homeostasis/metabolism
hematopoietic system
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• do not process caspase-1 and secrete less IL1B in response to LPS and ATP treatment
• impaired secretion of IL1A, IL1B and IL18 in TLR-primed and ATP-treated cells; however secretion of TNFA, IL6, and IL12 are similar to wild-type
• absence of bacterial muramyl dipeptide-stimulated IL1B secretion
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mortality/aging
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• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis
• genotype demonstrates inflammatory disease of the conditional allele does not require presence of wild-type allele
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immune system
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• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Flv mutation
(1 available);
any
Nlrp3 mutation
(61 available)
Slc11a1s mutation
(0 available);
any
Slc11a1 mutation
(40 available)
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mortality/aging
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• when infected with 105 Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1s homozygotes
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immune system
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• when infected with 105 Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1s homozygotes
• when infected with 105 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1s homozygotes
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Analysis Tools
