Analysis Tools
immune system
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• naive T cells are resistant to adenoviral infection, but transgenic T cells show greatly facitiated adenoviral vector entry and gene expression
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• transgenic T cells transduced by adenovirus encoding Bcl-xL show substantially reduced cell death in culture; activation with ConA enhances survival and expression of Bcl-xL
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• adenoviral mediated delivery of IkappaB superrepressor or p27KIP1 to mature transgenic T cells reduces proliferation in response to PMA/ConA stimulation; CrmA expression also blocks proliferation
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hematopoietic system
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• naive T cells are resistant to adenoviral infection, but transgenic T cells show greatly facitiated adenoviral vector entry and gene expression
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• transgenic T cells transduced by adenovirus encoding Bcl-xL show substantially reduced cell death in culture; activation with ConA enhances survival and expression of Bcl-xL
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• adenoviral mediated delivery of IkappaB superrepressor or p27KIP1 to mature transgenic T cells reduces proliferation in response to PMA/ConA stimulation; CrmA expression also blocks proliferation
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cellular
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• transgenic T cells transduced by adenovirus encoding Bcl-xL show substantially reduced cell death in culture; activation with ConA enhances survival and expression of Bcl-xL
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• adenoviral mediated delivery of IkappaB superrepressor or p27KIP1 to mature transgenic T cells reduces proliferation in response to PMA/ConA stimulation; CrmA expression also blocks proliferation
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