All Phenotypes Tg(Shh)#Dje MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Shh)#Dje
transgene insertion #, Douglas J Epstein
MGI:3665473

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ptch1^tm1Mps/Ptch1⁺ Tg(Shh)#Dje/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	MGI:3665561
cx2	Shh^tm1Chg/Shh⁺ Tg(Shh)#Dje/0	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	MGI:3665550
cx3	Gli1^tm1Alj/Gli1^tm1Alj Tg(Shh)#Dje/0	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	MGI:3665551
tg4	Tg(Shh)#Dje/0	involves: CD-1	MGI:3665488
tg5	Tg(Shh)#Dje/0	involves: Swiss Webster	MGI:3665497

Allelic Composition	Ptch1^tm1Mps/Ptch1⁺ Tg(Shh)#Dje/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1^tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Shh)#Dje mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum morphology ( J:108507 )

• cerebellum is larger than in Tg(Shh)#Dje-expressing mice

abnormal cerebellum development ( J:108507 )

• mutants have an extra lobule on rostral face of lobule VI

abnormal cerebellar foliation ( J:108507 )

• foliation is not enhanced compared to non transgenic conditional Gli2 knockouts

Allelic Composition	Shh^tm1Chg/Shh⁺ Tg(Shh)#Dje/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (1 available); any Shh mutation (45 available)
Tg(Shh)#Dje mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum morphology ( J:94461 )

• partial loss of Shh partially rescues Tg(Shh)#Dje phenotype; at E18.5, in some animals, cerebellum is slightly smaller than that of transgenics alone

abnormal cerebellar granule layer morphology ( J:94461 )

• IGL is not as thick or irregular as that of Shh transgenic mice and overall size is reduced

Allelic Composition	Gli1^tm1Alj/Gli1^tm1Alj Tg(Shh)#Dje/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1^tm1Alj mutation (0 available); any Gli1 mutation (48 available)
Tg(Shh)#Dje mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum morphology ( J:94461 )

• phenotype is similar to Tg(Shh)#Dje mice

abnormal cerebellar lobule formation ( J:94461 )

abnormal cerebellum external granule cell layer morphology ( J:94461 )

abnormal cerebellar granule layer morphology ( J:94461 )

cellular

abnormal cell proliferation ( J:94461 )

Allelic Composition	Tg(Shh)#Dje/0
Genetic Background	involves: CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

head bobbing ( J:79100 )

• observed in transgenic mice

hyperactivity ( J:79100 )

• observed in transgenic mice

circling ( J:79100 )

• circling (related to vestibular apparatus dysfunction) is observed

hearing/vestibular/ear

abnormal cochlear sensory epithelium morphology ( J:79100 )

• at E15.5, only 1 or 2 sensory patches are observed

abnormal scala media morphology ( J:79100 )

absent semicircular canals ( J:79100 )

• identifiable canals are absent at E15.5

abnormal inner ear vestibule morphology ( J:79100 )

• identifiable utricle and saccule are absent at E15.5

absent utricle ( J:79100 )

absent vestibular saccule ( J:79100 )

nervous system

abnormal vestibulocochlear ganglion morphology ( J:79100 )

• number of neurons contributing to cochleovestibular ganglion is increased 2 fold over wild-type at E10.5

Allelic Composition	Tg(Shh)#Dje/0
Genetic Background	involves: Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum morphology ( J:94461 , J:108507 )

• cerebellum is larger than wild-type especially in the AP axis in adult mutant (J:94461)

• mice develop larger cerebellum than controls (J:108507)

abnormal cerebellum external granule cell layer morphology ( J:94461 )

• at P14, EGL contains 3-4 cell layers vs a single layer in wild-type

• EGL persists until P16 while in normal littermates it is gone

abnormal cerebellar cortex morphology ( J:94461 )

• lobes in vermis and hemispheres are larger than in wild-type in adults

abnormal cerebellar granule layer morphology ( J:94461 , J:108507 )

• IGL is thicker and irregular compared to wild-type in lobes III, IV, V, and IX; overall, IGL in mutants is 30% larger than in wild-type in adults (J:94461)

• IGL surrounding primary fissure is irregular with distinct bulges (J:94461)

• IGL at P28 is more irregular than at P14 (J:94461)

• IGL is thicker and irregular compared to wild-type (J:108507)

cellular

abnormal cell proliferation ( J:94461 )

• cell proliferation is detected in mutant EGL at P16 while in wild-type it stops at P14

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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