Phenotypes associated with this allele

• Allele Symbol: Map3k7^tm1Zjc
• Allele Name: targeted mutation 1, Zhijian J Chen
• Allele ID: MGI:3665138
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Map3k7^tm1Zjc/Map3k7^tm1Zjc Tg(Lck-cre)548Jxm/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3701507

Genotype
MGI:3701507

cn1

• Allelic Composition: Map3k7^tm1Zjc/Map3k7^tm1Zjc; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased thymocyte apoptosis ( J:111794 )

• mutant single positive thymocytes are more sensitive to apoptosis than wild-type

decreased T cell number ( J:111794 )

• percentage of T cells in peripheral lymphoid organs is significantly lower than in controls

decreased CD4-positive, alpha-beta T cell number ( J:111794 )

• mature CD4+ T cells are reduced in number compared to controls

decreased CD8-positive, alpha-beta T cell number ( J:111794 )

• mature CD8+ T cells are reduced in number compared to controls

immune system

increased thymocyte apoptosis ( J:111794 )

• mutant single positive thymocytes are more sensitive to apoptosis than wild-type

decreased T cell number ( J:111794 )

• percentage of T cells in peripheral lymphoid organs is significantly lower than in controls

decreased CD4-positive, alpha-beta T cell number ( J:111794 )

• mature CD4+ T cells are reduced in number compared to controls

decreased CD8-positive, alpha-beta T cell number ( J:111794 )

• mature CD8+ T cells are reduced in number compared to controls

cellular

increased thymocyte apoptosis ( J:111794 )

• mutant single positive thymocytes are more sensitive to apoptosis than wild-type

endocrine/exocrine glands

increased thymocyte apoptosis ( J:111794 )

• mutant single positive thymocytes are more sensitive to apoptosis than wild-type