Map3k7^tm1Zjc
Targeted Allele Detail

Summary

• Symbol: Map3k7^tm1Zjc
• Name: mitogen-activated protein kinase kinase kinase 7; targeted mutation 1, Zhijian J Chen
• MGI ID: MGI:3665138
• Synonyms: Tak1^FL
• Gene: Map3k7 Location: Chr4:31964097-32023467 bp, + strand Genetic Position: Chr4, 13.91 cM
• Alliance: Map3k7^tm1Zjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111794
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 is flanked between a loxP site before the transcriptional initiation site and another loxP site within intron 1. A FRT-neo-FRT selection cassette was also inserted before the intronic loxP site. (J:111794)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k7 Mutation: 51 strains or lines available

References

• Original: J:111794 Liu HH, et al., Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11677-82
• All: 9 reference(s)