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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nodaltm1.1Dbc
targeted mutation 1.1, Daniel B Constam
MGI:3664774
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nodaltm1.1Dbc/Nodaltm1.1Dbc involves: 129S/SvEv * C57BL/6 MGI:3664778


Genotype
MGI:3664778
hm1
Allelic
Composition		 Nodaltm1.1Dbc/Nodaltm1.1Dbc
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm1.1Dbc mutation (0 available); any Nodal mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal mesendoderm development ( J:112799 )
• expression analysis indicates that mesendodermal progenitor cells are absent
embryonic growth arrest ( J:112799 )
• arrest during gastrulation
abnormal primitive streak formation ( J:112799 )
• the entire epiblast assumes a mesenchymal fate indicating ectopic primitive streak formation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory