Phenotypes associated with this allele

• Allele Symbol: Neurog2^{tm5(Neurog2)Fgu}
• Allele Name: targeted mutation 5, Francois Guillemot
• Allele ID: MGI:3664585
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neurog2^tm5(Neurog2)Fgu/Neurog2^tm5(Neurog2)Fgu	involves: 129S1/Sv * 129X1/SvJ	MGI:3703640

Genotype
MGI:3703640

hm1

• Allelic Composition: Neurog2^{tm5(Neurog2)Fgu}/Neurog2^{tm5(Neurog2)Fgu}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:109091 )

• acute deletion of Neurog2 by electroporation with Cre results in decreased expression of neuronal differentiation marker HuC/D; conversely, overexpression of Neurog2 from the knockin allele promotes neuronal differentiation in cultured cells

abnormal neuronal migration ( J:109091 )

• in cortices 4 days after electroporation with Cre, fewer cortical cells reach the cortical plate than in wild-type

• Neurog overexpression results in a small, significant increase in numbers of cells reaching the cortical plate

cellular

abnormal neuron differentiation ( J:109091 )

• acute deletion of Neurog2 by electroporation with Cre results in decreased expression of neuronal differentiation marker HuC/D; conversely, overexpression of Neurog2 from the knockin allele promotes neuronal differentiation in cultured cells

abnormal neuronal migration ( J:109091 )

• in cortices 4 days after electroporation with Cre, fewer cortical cells reach the cortical plate than in wild-type

• Neurog overexpression results in a small, significant increase in numbers of cells reaching the cortical plate