Analysis Tools
immune system
| N |
• homozygotes produce normal concentrations of serum antibodies, most of which carry chimeric (mouse V and human C regions) kappa light chains, mount normal immune responses to hapten-protein conjugates, and antigen-specific B cells undergo affinity maturation through somatic hypermutation to the same extent as wild-type
|
|
• production of kappa chain-expressing B cells is less efficient as mutants exhibit only half as many B cells in the spleen, 17% of which express lambda chains compared to 5% in wild-type
|
hematopoietic system
|
• production of kappa chain-expressing B cells is less efficient as mutants exhibit only half as many B cells in the spleen, 17% of which express lambda chains compared to 5% in wild-type
|
