Phenotypes associated with this allele

• Allele Symbol: Slc24a2^tm1Jlyt
• Allele Name: targeted mutation 1, Johathan Lytton
• Allele ID: MGI:3663782
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc24a2^tm1Jlyt/Slc24a2^tm1Jlyt	either: B6.129-Slc24a2^tm1Jlyt or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:3686865

Genotype
MGI:3686865

hm1

• Allelic Composition: Slc24a2^tm1Jlyt/Slc24a2^tm1Jlyt
• Genetic Background: either: B6.129-Slc24a2^tm1Jlyt or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

reduced long-term potentiation ( J:110313 )

• exhibit a profound loss of long term potentiation at hippocampal Schaffer/CA1 synapses

abnormal long-term depression ( J:110313 )

• exhibit an increase in long term depression at hippocampal Schaffer/CA1 synapses

behavior/neurological

abnormal motor learning ( J:110313 )

• first display normal performance in the rotarod but are unable to improve their performance with time like wild-type

abnormal spatial learning ( J:110313 )

• in the Morris water maze, do not show an improved performance on the moving platform task as do wild-type, however performance on the fixed hidden platform is similar to wild-type

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:110313 )

• exhibit a significant reduction in calcium flux in cortical neurons

vision/eye

vision/eye phenotype ( J:110313 )

N • exhibit normal cones and visual transduction