Slc24a2^tm1Jlyt
Targeted Allele Detail

Summary

• Symbol: Slc24a2^tm1Jlyt
• Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; targeted mutation 1, Johathan Lytton
• MGI ID: MGI:3663782
• Synonyms: Nckx2^-
• Gene: Slc24a2 Location: Chr4:86901361-87148714 bp, - strand Genetic Position: Chr4, 40.69 cM
• Alliance: Slc24a2^tm1Jlyt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110313
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting vector was designed to replace part of exon 2 with a neomycin resistance cassette in reverse orientation. Transcript was not detected in Northern blot of mutant brains. Immunoblot failed to detect protein in mutant brain samples. (J:110313)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc24a2 Mutation: 44 strains or lines available

References

• Original: J:110313 Li XF, et al., Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory. J Biol Chem. 2006 Mar 10;281(10):6273-82
• All: 1 reference(s)