All Phenotypes Ark2c<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ark2c⁺
wild type
MGI:3663767

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ark2c^Gt(P9-3F)Sor/Ark2c⁺ Smad9^tm1Rob/Smad9^tm1Rob Tg(Hlxb9-GFP)1Tmj/0	involves: 129S/SvEv * C57BL/6 * CBA	MGI:5516590
cx2	Bmpr2^tm1Kmi/Bmpr2⁺ Ark2c^Gt(P9-3F)Sor/Ark2c⁺ Tg(Hlxb9-GFP)1Tmj/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5516589

Allelic Composition	Ark2c^Gt(P9-3F)Sor/Ark2c⁺ Smad9^tm1Rob/Smad9^tm1Rob Tg(Hlxb9-GFP)1Tmj/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ark2c^Gt(P9-3F)Sor mutation (0 available); any Ark2c mutation (11 available)
Smad9^tm1Rob mutation (2 available); any Smad9 mutation (30 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:198828 )

• fewer than expected mice survive prior to weaning

prenatal lethality, incomplete penetrance ( J:198828 )

• fewer than expected mice are born

muscle

skeletal muscle atrophy ( J:198828 )

• unilateral penetrance in the muscles controlling the digits and wrist

behavior/neurological

decreased grip strength ( J:198828 )

• some mice exhibit reduced hang time from a cage lid compared with wild-type mice

nervous system

abnormal motor neuron innervation pattern ( J:198828 )

• reduction or loss of the most distal innervation in the forelimbs

skeleton

abnormal joint mobility ( J:198828 )

• as in Rnf165 homozygotes

limbs/digits/tail

abnormal forelimb morphology ( J:198828 )