Phenotypes associated with this allele

• Allele Symbol: Pde10a^tm1Pfi
• Allele Name: targeted mutation 1, Pfizer, Ltd
• Allele ID: MGI:3663426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde10a^tm1Pfi/Pde10a^tm1Pfi	DBA/1LacJ-Pde10a^tm1Pfi	MGI:3663933

Genotype
MGI:3663933

hm1

• Allelic Composition: Pde10a^tm1Pfi/Pde10a^tm1Pfi
• Genetic Background: DBA/1LacJ-Pde10a^tm1Pfi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:111662 )

• female homozygotes have significantly lower body weights than corresponding wild-type mice (12% decrease) while body weight in males is equivalent in mutants and wild-type

behavior/neurological

abnormal avoidance learning behavior ( J:111662 )

• mutants show a delay in acquisition of conditioned avoidance behavior

decreased exploration in new environment ( J:111662 )

• mutants show decreased exploratory and/or locomotor activity in open field tests

decreased locomotor activity ( J:111662 )

• male homozygotes show decreased locomotor activity compared to wild-type males when placed in a novel environment (29% decrease in locomotor activity at 30 minutes); difference disappears by 60 minutes

• in an elevated plus maze test, no differences in open arm entries or time spent in open arms are observed, but the total distance traveled by homozygotes is significantly less than wild-type (28% decrease in males, 17% decrease in females)

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:111662 )

• phospodiesterase (PDE) activity immunoprecipitated from the striatum is substantially reduced in homozygotes vs wild-type; null mice lack PDE activity while heterozygotes have only slightly less activity than wild-type

• no difference in activity precipitated from the cortex is seen between homozygotes, heterozygotes and wild-type