Phenotypes associated with this allele

• Allele Symbol: Vdr^tm2Ska
• Allele Name: targeted mutation 2, Shigeaki Kato
• Allele ID: MGI:3663379
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vdr^tm2Ska/Vdr^tm2Ska	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:3663451
cn2	Vdr^tm2Ska/Vdr^tm2Ska Tg(KRT14-cre)1Ipc/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL	MGI:3663452
cn3	Tg(Col1a1-cre)1Kry/0 Vdr^tm2Ska/Vdr^tm2Ska	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * FVB/N	MGI:5501520

Genotype
MGI:3663451

hm1

• Allelic Composition: Vdr^tm2Ska/Vdr^tm2Ska
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

ear inflammation ( J:111828 )

• topical application of MC903 a low calcemic analog of vitamin D to the ears results in obvious inflammation by day 17

immune system

ear inflammation ( J:111828 )

• topical application of MC903 a low calcemic analog of vitamin D to the ears results in obvious inflammation by day 17

integument

mixed cellular infiltration to dermis ( J:111828 )

• massive dermal infiltrate of eosinophils , CD4+ T cells, dendritic cells and mast cells is detected in ears of MC903-treated mice

Genotype
MGI:3663452

cn2

• Allelic Composition: Vdr^tm2Ska/Vdr^tm2Ska; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

integument

integument phenotype ( J:111828 )

N • topical application of MC903 a low calcemic analog of vitamin D to the ears does not cause obvious inflammation of the skin compared to Vdr^tm1Pcn homozygous controls

Genotype
MGI:5501520

cn3

• Allelic Composition: Tg(Col1a1-cre)1Kry/0; Vdr^tm2Ska/Vdr^tm2Ska
• Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

skeleton

skeleton phenotype ( J:196471 )

N • osteoblasts exhibit normal mineral metabolism

N • cortical thickness in the femur is normal at 16 weeks

abnormal osteoclast differentiation ( J:196471 )

• impaired

decreased osteoclast cell number ( J:196471 )

increased bone mineral density ( J:196471 )

• at 16 weeks

increased trabecular bone volume ( J:196471 )

• at 16 weeks

• however, trabecular bone volume of the distal femoral metaphysis at 4 and 9 weeks is normal

increased bone mass ( J:196471 )

• at 16 weeks

decreased bone resorption ( J:196471 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196471 )

N • mice exhibit normocalcemia and normophosphatemia

cellular

abnormal osteoclast differentiation ( J:196471 )

• impaired

immune system

abnormal osteoclast differentiation ( J:196471 )

• impaired

decreased osteoclast cell number ( J:196471 )

hematopoietic system

abnormal osteoclast differentiation ( J:196471 )

• impaired

decreased osteoclast cell number ( J:196471 )