Phenotypes associated with this allele
Allelic Composition |
Vdrtm2Ska/Vdrtm2Ska
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Genetic Background |
involves: C57BL/6NCrlj * CBA/JNCrlj |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vdrtm2Ska mutation
(1 available);
any
Vdr mutation
(35 available)
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hearing/vestibular/ear
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• topical application of MC903 a low calcemic analog of vitamin D to the ears results in obvious inflammation by day 17
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immune system
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• topical application of MC903 a low calcemic analog of vitamin D to the ears results in obvious inflammation by day 17
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integument
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• massive dermal infiltrate of eosinophils , CD4+ T cells, dendritic cells and mast cells is detected in ears of MC903-treated mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Ipc mutation
(0 available)
Vdrtm2Ska mutation
(1 available);
any
Vdr mutation
(35 available)
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integument
N |
• topical application of MC903 a low calcemic analog of vitamin D to the ears does not cause obvious inflammation of the skin compared to Vdrtm1Pcn homozygous controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col1a1-cre)1Kry mutation
(2 available)
Vdrtm2Ska mutation
(1 available);
any
Vdr mutation
(35 available)
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skeleton
N |
• osteoblasts exhibit normal mineral metabolism
• cortical thickness in the femur is normal at 16 weeks
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• at 16 weeks
• however, trabecular bone volume of the distal femoral metaphysis at 4 and 9 weeks is normal
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homeostasis/metabolism
cellular
immune system
hematopoietic system