Vdr^tm2Ska
Targeted Allele Detail

Summary

• Symbol: Vdr^tm2Ska
• Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 2, Shigeaki Kato
• MGI ID: MGI:3663379
• Synonyms: VDR^L2, Vdr^tm1Pcn
• Gene: Vdr Location: Chr15:97752308-97806177 bp, - strand Genetic Position: Chr15, 53.85 cM
• Alliance: Vdr^tm2Ska page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111828
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin (neo) resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and left exon 3 floxed. (J:196471)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vdr Mutation: 35 strains or lines available

References

• Original: J:111828 Li M, et al., Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41
• All: 23 reference(s)