Phenotypes associated with this allele

• Allele Symbol: Slc18a1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3663332
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc18a1^tm1Dgen/Slc18a1^tm1Dgen	B6.129P2-Slc18a1^tm1Dgen/J	MGI:5474787
hm2	Slc18a1^tm1Dgen/Slc18a1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3663341

Genotype
MGI:5474787

hm1

• Allelic Composition: Slc18a1^tm1Dgen/Slc18a1^tm1Dgen
• Genetic Background: B6.129P2-Slc18a1^tm1Dgen/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:194189 )

• in the dentate gyrus

abnormal neuron proliferation ( J:194189 )

• increased in the hippocampus

behavior/neurological

behavior/neurological phenotype ( J:194189 )

N • mice exhibit normal contextual fear conditioning

abnormal object recognition memory ( J:194189 )

• mice exhibit impaired spatial object recognition compared with wild-type mice

cellular

increased neuron apoptosis ( J:194189 )

• in the dentate gyrus

abnormal neuron proliferation ( J:194189 )

• increased in the hippocampus

Genotype
MGI:3663341

hm2

• Allelic Composition: Slc18a1^tm1Dgen/Slc18a1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:101679 )

N