All Phenotypes Ret<tm1.1Kln> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm1.1Kln
targeted mutation 1.1, Rudiger Klein
MGI:3662902

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm1.1Kln/Ret^tm1.1Kln	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	MGI:3662905
cx2	Lhx1^tm1Tmj/Lhx1⁺ Ret^tm1.1Kln/Ret^tm1.1Kln	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	MGI:3662907
cx3	Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Ret^tm1.1Kln/Ret^tm1.1Kln	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J	MGI:3662909

Allelic Composition	Ret^tm1.1Kln/Ret^tm1.1Kln
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1.1Kln mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:110955 )

• at E11.5 in nulls, the developing ventral branch of axons coming from the sciatic plexus appear thicker while the dorsal branch is reduced; most embryos displayed defects categorized as intermediate reductions (Category II: intermediate reductions)

• at E12.5 the branchpoint of peroneal nerve (PN) seen in wild-type is absent or has become the most distal extension of the peroneal nerve which is also reduced in diameter; in most severe cases, nerve is almost completely absent

• mutants have peroneal nerves of reduced length (~40% of control) at E11.5

Allelic Composition	Lhx1^tm1Tmj/Lhx1⁺ Ret^tm1.1Kln/Ret^tm1.1Kln
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1^tm1Tmj mutation (0 available); any Lhx1 mutation (22 available)
Ret^tm1.1Kln mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

cellular

abnormal axon guidance ( J:110955 )

• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve

• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls

Allelic Composition	Epha4^{Gt(PST038)Byg}/Epha4^{Gt(PST038)Byg} Ret^tm1.1Kln/Ret^tm1.1Kln
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4^{Gt(PST038)Byg} mutation (1 available); any Epha4 mutation (66 available)
Ret^tm1.1Kln mutation (0 available); any Ret mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:110955 )

• mice show severe axon guidance defects

• all embryos have severely affected, Category III phenotypes; peroneal nerve is severely shortened and often defasciculated

abnormal innervation pattern to muscle ( J:110955 )

cellular

abnormal axon guidance ( J:110955 )

• mice show severe axon guidance defects

• all embryos have severely affected, Category III phenotypes; peroneal nerve is severely shortened and often defasciculated

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