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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rfngtm2Tfv
targeted mutation 2, Thomas F Vogt
MGI:3662621
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rfngtm2Tfv/Rfngtm2Tfv involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3663787
hm2
 		Rfngtm2Tfv/Rfngtm2Tfv involves: 129P2/OlaHsd * C57BL/6J MGI:3663786


Genotype
MGI:3663787
hm1
Allelic
Composition		 Rfngtm2Tfv/Rfngtm2Tfv
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rfngtm2Tfv mutation (0 available); any Rfng mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:110952 )
• no homozygous mouse survived past birth




Genotype
MGI:3663786
hm2
Allelic
Composition		 Rfngtm2Tfv/Rfngtm2Tfv
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rfngtm2Tfv mutation (0 available); any Rfng mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:110952 )
• no homozygous mouse survived past birth

craniofacial
short mandible ( J:110952 )
• examined between E18.5 and birth
cleft secondary palate ( J:110952 )
• examined between E18.5 and birth
• the maxillary shelves are more widely spaced than controls
failure of palatal shelf elevation ( J:110952 )
• in homozygotes, palatal shelves have not elevated towards the midline

skeleton
short mandible ( J:110952 )
• examined between E18.5 and birth

limbs/digits/tail
oligodactyly ( J:110952 )
• examined between E18.5 and birth
syndactyly ( J:110952 )
• soft-tissue syndactyly examined between E18.5 and birth

digestive/alimentary system
cleft secondary palate ( J:110952 )
• examined between E18.5 and birth
• the maxillary shelves are more widely spaced than controls
failure of palatal shelf elevation ( J:110952 )
• in homozygotes, palatal shelves have not elevated towards the midline

growth/size/body
short mandible ( J:110952 )
• examined between E18.5 and birth
cleft secondary palate ( J:110952 )
• examined between E18.5 and birth
• the maxillary shelves are more widely spaced than controls
failure of palatal shelf elevation ( J:110952 )
• in homozygotes, palatal shelves have not elevated towards the midline




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory