Phenotypes associated with this allele

• Allele Symbol: Gata6^tm2.2Sad
• Allele Name: targeted mutation 2.2, Steven A Duncan
• Allele ID: MGI:3656027
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata6^tm2.2Sad/Gata6^tm2.2Sad	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:5780585
hm2	Gata6^tm2.2Sad/Gata6^tm2.2Sad	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N	MGI:3662658
ht3	Gata6^tm2.2Sad/Gata6^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5780589
ht4	Gata6^tm2.2Sad/Gata6^+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:5780586
cn5	Gata6^tm2.1Sad/Gata6^tm2.2Sad Tg(EIIa-cre)C5379Lmgd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL	MGI:3662656
cx6	Gata6^tm2.2Sad/Gata6^tm2.2Sad Pdgfra^tm11(EGFP)Sor/Pdgfra^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:5780588

Genotype
MGI:5780585

hm1

• Allelic Composition: Gata6^tm2.2Sad/Gata6^tm2.2Sad
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

absent primitive endoderm ( J:217512 )

• as determined by marker expression

• Fgf4 administration does not rescue primitive endoderm specification

Genotype
MGI:3662658

hm2

• Allelic Composition: Gata6^tm2.2Sad/Gata6^tm2.2Sad
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N

mortality/aging

embryonic lethality, complete penetrance ( J:111388 )

• between E8.5 and E11.5 all appear to be partially resorbed empty decidual masses

Genotype
MGI:5780589

ht3

• Allelic Composition: Gata6^tm2.2Sad/Gata6⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

embryo

absent primitive endoderm ( J:213580 )

Genotype
MGI:5780586

ht4

• Allelic Composition: Gata6^tm2.2Sad/Gata6⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

embryo

abnormal primitive endoderm morphology ( J:217512 )

• fewer than expected proportion of primitive endoderm cells in early embryos

• however, primitive endoderm populations have recovered by E4.5

Genotype
MGI:3662656

cn5

• Allelic Composition: Gata6^tm2.1Sad/Gata6^tm2.2Sad; Tg(EIIa-cre)C5379Lmgd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:111388 )

• between E8.5 and E11.5 all Cre positive double mutants appear to be partially resorbed empty decidual masses

Genotype
MGI:5780588

cx6

• Allelic Composition: Gata6^tm2.2Sad/Gata6^tm2.2Sad; Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

embryo

absent primitive endoderm ( J:213580 )