All Phenotypes Gata6<tm2.2Sad> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata6^tm2.2Sad
targeted mutation 2.2, Steven A Duncan
MGI:3656027

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata6^tm2.2Sad/Gata6^tm2.2Sad	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:5780585
hm2	Gata6^tm2.2Sad/Gata6^tm2.2Sad	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N	MGI:3662658
ht3	Gata6^tm2.2Sad/Gata6⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5780589
ht4	Gata6^tm2.2Sad/Gata6⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:5780586
cn5	Gata6^tm2.1Sad/Gata6^tm2.2Sad Tg(EIIa-cre)C5379Lmgd/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL	MGI:3662656
cx6	Gata6^tm2.2Sad/Gata6^tm2.2Sad Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:5780588

Allelic Composition	Gata6^tm2.2Sad/Gata6^tm2.2Sad
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6^tm2.2Sad mutation (0 available); any Gata6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

absent primitive endoderm ( J:217512 )

• as determined by marker expression

• Fgf4 administration does not rescue primitive endoderm specification

Allelic Composition	Gata6^tm2.2Sad/Gata6^tm2.2Sad
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6^tm2.2Sad mutation (0 available); any Gata6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:111388 )

• between E8.5 and E11.5 all appear to be partially resorbed empty decidual masses

Allelic Composition	Gata6^tm2.2Sad/Gata6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6^tm2.2Sad mutation (0 available); any Gata6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

absent primitive endoderm ( J:213580 )

Allelic Composition	Gata6^tm2.2Sad/Gata6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6^tm2.2Sad mutation (0 available); any Gata6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal primitive endoderm morphology ( J:217512 )

• fewer than expected proportion of primitive endoderm cells in early embryos

• however, primitive endoderm populations have recovered by E4.5

Allelic Composition	Gata6^tm2.1Sad/Gata6^tm2.2Sad Tg(EIIa-cre)C5379Lmgd/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6^tm2.1Sad mutation (1 available); any Gata6 mutation (32 available)
Gata6^tm2.2Sad mutation (0 available); any Gata6 mutation (32 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:111388 )

• between E8.5 and E11.5 all Cre positive double mutants appear to be partially resorbed empty decidual masses

Allelic Composition	Gata6^tm2.2Sad/Gata6^tm2.2Sad Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6^tm2.2Sad mutation (0 available); any Gata6 mutation (32 available)
Pdgfra^{tm11(EGFP)Sor} mutation (1 available); any Pdgfra mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

absent primitive endoderm ( J:213580 )

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