Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1Gt(XM256)6Byg mutation
(0 available);
any
Gars1 mutation
(42 available)
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Allelic
Composition |
Gars1Gt(XM256)6Byg/Gars1+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1Gt(XM256)6Byg mutation
(0 available);
any
Gars1 mutation
(42 available)
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normal phenotype
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• no nervous system phenotype; no axonal degeneration is seen, with large-caliber axons and neuromuscular synapses with normal morphology present and normal nerve conduction velocities
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1C201R mutation
(2 available);
any
Gars1 mutation
(42 available)
Gars1Gt(XM256)6Byg mutation
(0 available);
any
Gars1 mutation
(42 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1Gt(XM256)6Byg mutation
(0 available);
any
Gars1 mutation
(42 available)
Gars1Nmf249 mutation
(1 available);
any
Gars1 mutation
(42 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1C201R mutation
(2 available);
any
Gars1 mutation
(42 available)
Gars1Gt(XM256)6Byg mutation
(0 available);
any
Gars1 mutation
(42 available)
Tg(CAG-GARS)DRwb mutation
(0 available)
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mortality/aging
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N |
• mutants are born at the expected Mendelian ratios, indicating rescue of the embryonic lethality observed in compound heterozygotes without the transgene
• while embryonic lethality is rescued with the transgene, severity of neuropathy is similar to single GarsC201R heterozygotes
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growth/size/body
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• mutants exhibit lower body weights than single GarsGt(XM256)6Byg heterozygotes or wild-type mice
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nervous system
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N |
• mutants exhibit normal numbers of myelinated axons in the motor or sensory branch of the fremoral nerve
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• neuromuscular junctions have regions of immature morphology or denervation, similar to single GarsC201R heterozygotes
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• mutants exhibit reduced nerve conduction velocities, but they are similar to single GarsC201R heterozygotes
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Analysis Tools