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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mavs+
wild type
MGI:3654504
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Mavstm1Zjc/Mavs+ involves: 129/Sv * C57BL/6 MGI:3654505
cx2
 		Ifih1Rgsc422/Ifih1+
Mavstm1Aki/Mavs+ 		involves: C57BL/6JJcl * DBA/2JJcl MGI:5617221


Genotype
MGI:3654505
ht1
Allelic
Composition		 Mavstm1Zjc/Mavs+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavstm1Zjc mutation (1 available); any Mavs mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal innate immunity ( J:110905 )
• intermediate levels of IFNalpha, IFNbeta and Il-6 are found in the sera of heterozygotes after injection of poly(I:C)
increased susceptibility to Riboviria infection ( J:110905 )
• all heterozygotes die within 4 days of infection with VSV (vesicular stomatitis virus) while wild-type survive; with infection by 2 x 108 of the less virulent VSV-GFP, 2/5 heterozygotes survive 8 days while 5/7 wild-type survive 12 days and infection with half the viral titer, 3 out of 4 survive past 12 days




Genotype
MGI:5617221
cx2
Allelic
Composition		 Ifih1Rgsc422/Ifih1+
Mavstm1Aki/Mavs+
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation (0 available); any Ifih1 mutation (50 available)
Mavstm1Aki mutation (0 available); any Mavs mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
glomerulonephritis ( J:209917 )
• less severe than in mice wild-type for Mavs

renal/urinary system
glomerulonephritis ( J:209917 )
• less severe than in mice wild-type for Mavs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory