Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation
(0 available);
any
Igh mutation
(43 available)
Ightm4Cgn mutation
(0 available);
any
Igh mutation
(43 available)
Tg(Igk-V4CH27)1-2Shc mutation
(0 available)
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hematopoietic system
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• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants
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immune system
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• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igll1tm1Cgn mutation
(1 available);
any
Igll1 mutation
(16 available)
Tg(Igk-V4CH27)1-2Shc mutation
(0 available)
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immune system
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• more than 80% of CD43+ B cell progenitors express the transgene in the cytoplasm, compared to only 22% of wild-type cells at a similar developmental stage which express a kappa chain
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• about a 3- to 4-fold reduction in pre-B cells; however, the overall numbers of immature and mature B cell numbers are similar to wild-type
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hematopoietic system
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• more than 80% of CD43+ B cell progenitors express the transgene in the cytoplasm, compared to only 22% of wild-type cells at a similar developmental stage which express a kappa chain
|
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• about a 3- to 4-fold reduction in pre-B cells; however, the overall numbers of immature and mature B cell numbers are similar to wild-type
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation
(0 available);
any
Igh mutation
(43 available)
Tg(Igk-V4CH27)1-2Shc mutation
(0 available)
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hematopoietic system
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• mice have 2-fold more splenic B cells than Ightm1Kplm mutants and 8-fold more cells than Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants
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immune system
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• mice have 2-fold more splenic B cells than Ightm1Kplm mutants and 8-fold more cells than Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants
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