All Phenotypes Sox6<tm2.1Vlf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox6^tm2.1Vlf
targeted mutation 2.1, Veronique Lefevbre
MGI:3641204

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox6^tm2.1Vlf/Sox6^tm2.1Vlf Tg(Prrx1-cre)1Cjt/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL	MGI:3800360
cn2	Sox5^tm2Vlf/Sox5^tm2Vlf Sox6^tm2.1Vlf/Sox6^tm2.1Vlf Tg(Prrx1-cre)1Cjt/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL	MGI:3800358
cn3	Sox5^tm1Vlf/Sox5^tm1Vlf Sox6^tm1Vlf/Sox6^tm2.1Vlf Tg(Col2a1-cre)1Bhr/0	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3641207

Allelic Composition	Sox6^tm2.1Vlf/Sox6^tm2.1Vlf Tg(Prrx1-cre)1Cjt/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox6^tm2.1Vlf mutation (0 available); any Sox6 mutation (59 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:137217 )

• normal appearance at birth

• viable and fertile

Allelic Composition	Sox5^tm2Vlf/Sox5^tm2Vlf Sox6^tm2.1Vlf/Sox6^tm2.1Vlf Tg(Prrx1-cre)1Cjt/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox5^tm2Vlf mutation (0 available); any Sox5 mutation (44 available)
Sox6^tm2.1Vlf mutation (0 available); any Sox6 mutation (59 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:137217 )

• small size

limbs/digits/tail

abnormal limb morphology ( J:137217 )

abnormal autopod morphology ( J:137217 )

• paws lack mineralized bone

abnormal radius morphology ( J:137217 )

• lacks cartillage

abnormal ulna morphology ( J:137217 )

• lacks cartillage

abnormal fibula morphology ( J:137217 )

• lacks cartillage

abnormal tibia morphology ( J:137217 )

• lacks cartillage

short limbs ( J:137217 )

skeleton

abnormal radius morphology ( J:137217 )

• lacks cartillage

abnormal ulna morphology ( J:137217 )

• lacks cartillage

abnormal fibula morphology ( J:137217 )

• lacks cartillage

abnormal tibia morphology ( J:137217 )

• lacks cartillage

short sternum ( J:137217 )

• at birth

Allelic Composition	Sox5^tm1Vlf/Sox5^tm1Vlf Sox6^tm1Vlf/Sox6^tm2.1Vlf Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox5^tm1Vlf mutation (0 available); any Sox5 mutation (44 available)
Sox6^tm1Vlf mutation (0 available); any Sox6 mutation (59 available)
Sox6^tm2.1Vlf mutation (0 available); any Sox6 mutation (59 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal cartilage development ( J:110147 )

• poorly developed cartilage similar to double homozygous mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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