Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1.1Tes mutation
(0 available);
any
Ntrk2 mutation
(66 available)
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behavior/neurological
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• mice spend less time and make fewer entries into the middle of an open field test
• mice spend less than a third of the time as controls in the open arms of elevated plus maze test
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nervous system
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• there is a decrease in dendritic arbor complexity at 90 micrometers and greater distances from the soma for neurons within the amygdale
• there is also a decrease in dendritic length for these neurons
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• there is a decrease in dendritic arbor complexity at 90 micrometers and greater distances from the soma for neurons within the amygdale
• there is also a decrease in dendritic length for these neurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1.1Tes mutation
(0 available);
any
Ntrk2 mutation
(66 available)
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nervous system
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• at E13, male mice exhibit increased sensory neurons innervating the mammary gland compared with wild-type mice
• however, female mice exhibit normal mammary gland innervation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1.1Tes mutation
(0 available);
any
Ntrk2 mutation
(66 available)
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behavior/neurological
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• mice spend less time and make fewer entries into the middle of an open field test
• mice spend less than two-thirds of the time as controls in the open arms of elevated plus maze test
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(41 available)
Ntrk2tm1.1Tes mutation
(0 available);
any
Ntrk2 mutation
(66 available)
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behavior/neurological
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• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls
• male mice also have a significantly increased number of biting attacks over a 5 minute period
• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnftm1Par mutant allele
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growth/size/body
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• mice gain weight with age though not to the degree as mice that only carry the Bdnftm1Par mutant allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(41 available)
Ntrk2tm1.1Tes mutation
(0 available);
any
Ntrk2 mutation
(66 available)
|
|
|
behavior/neurological
|
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• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls
• male mice also have a significantly increased number of biting attacks over a 5 minute period
• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnftm1Par mutant allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1.1Tes mutation
(0 available);
any
Ntrk2 mutation
(66 available)
Rb(12.Ts171665Dn)2Cje mutation
(1 available);
any
Rb(12.Ts171665Dn)2Cje mutation
(1 available)
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nervous system
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N |
• the Ntrk2tm1.1Tes allele rescues the increased apoptosis of cortical cells in vivo, and the accelerated death of hippocampal neurons in vitro that occurs with cells carrying the Rb(12.Ts171665Dn)2Cje allele
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Analysis Tools