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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmed10tm1Mjo
targeted mutation 1, Michael J Owen
MGI:3640663
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmed10tm1Mjo/Tmed10tm1Mjo involves: 129P2/OlaHsd * C57BL/6 MGI:3641443
ht2
 		Tmed10tm1Mjo/Tmed10+ involves: 129P2/OlaHsd * C57BL/6 MGI:3641444


Genotype
MGI:3641443
hm1
Allelic
Composition		 Tmed10tm1Mjo/Tmed10tm1Mjo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmed10tm1Mjo mutation (0 available); any Tmed10 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:95650 )
• no blastocyts are found at E3.5 and no homozygous ES cells could be generated




Genotype
MGI:3641444
ht2
Allelic
Composition		 Tmed10tm1Mjo/Tmed10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmed10tm1Mjo mutation (0 available); any Tmed10 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal Golgi apparatus morphology ( J:95650 )
• in the kidney and liver, the saccules of the Golgi apparatus are more dilated and the number of vacuoles surrounding the Golgi appear to be increased




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory