Tmed10^tm1Mjo
Targeted Allele Detail

Summary

• Symbol: Tmed10^tm1Mjo
• Name: transmembrane p24 trafficking protein 10; targeted mutation 1, Michael J Owen
• MGI ID: MGI:3640663
• Synonyms: p23^-
• Gene: Tmed10 Location: Chr12:85387388-85421491 bp, - strand Genetic Position: Chr12, 39.65 cM
• Alliance: Tmed10^tm1Mjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95650
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the first exon, including the ATG, with a neomycin resistance cassette. Northern and Western blot confirmed a decrease in protein and transcript in heterozygous mice, respectively. (J:95650)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmed10 Mutation: 50 strains or lines available

References

• Original: J:95650 Denzel A, et al., The p24 family member p23 is required for early embryonic development. Curr Biol. 2000 Jan 13;10(1):55-8
• All: 2 reference(s)