Analysis Tools
mortality/aging
|
• survival is impaired in a non-pathogen-free environment but is similar to wild-type in a pathogen-free environment
|
immune system
|
• increase in the number of apoptotic marcophages in medullary areas of the thymus and in splenic marginal zones
|
|
• enlarged with increased red and white pulp areas
|
|
• dramatic enlargement of the lymphatic follicles compressing and displacing the red pulp to the periphery; however T cell areas are not enlarged
|
|
• 7 days after immunization with a T cell dependent antigen fewer and poorly defined germinal centers develop
|
|
• mild to moderate increase in the number of normoblasts and megakaryocytes and decreased numbers of metachromic macrophages
• after 5 months of age, a 1.5- to 2.5-fold increase in the total number and percentage of B cells is seen correlating with the enlarged white pulp area
|
|
• following intravenous injection with glucan only small scattered granulomas containing mostly macrophages with very few granulocytes are formed
|
|
• increased 2-fold
|
|
• IgG2a is increased 2-fold
|
|
• levels of IgG1, IgG2b, and IgG3 are reduced 3-, 2-, and 4-fold, respectively
|
|
• increased 3-fold
|
|
• T cell levels of GM-CSF and TNFA are increased but levels of IL-2 are similar to wild-type
|
|
• resident peritoneal macrophages produce less NO following stimulation with LPS and TNFG
• basal levels of IL-1b, GM-CSF, TNFA, and IL-6 and LPS and IFNG-stimulated levels of IL-1b and GM-CSF, but not TNFA and IL-6, are reduced in resident peritoneal macrophages
|
|
• a 2-fold reduction in the number of peritoneal macrophages is seen following thioglycollate injection along with this there is a relative increase in the number of polymorphonuclear leukocytes
|
dermatitis
(
J:46911
)
|
• after 5 to 7 months of age, slowly progressing eczematoid skin lesions develop around the nose, ears, eyes, tails, and foreskin
• these lesions are not related to infections and do not compromise survival of mice kept in pathogen free conditions; however in non-pathogen-free environments survival is decreased
|
|
• 5 days after intraperitoneal infection with L. monocytogenes, homozygotes display greater than 20-fold higher titers in the spleen, liver, and lungs
• however, viral titers 3 or 7 days after infection with lymphocytic choriomeningitis virus are similar to wild-type
|
digestive/alimentary system
|
• change in color and consistency in 30% of mice
|
respiratory system
|
• change in color and consistency in 30% of mice
|
skeleton
|
• 30% display pale bones
|
liver/biliary system
|
• change in color and consistency in 30% of mice
|
hematopoietic system
|
• after 5 months of age, an increase in erythroid precursors and granulocytes are seen in the enlarged spleen
|
|
• decreased cellularity and some empty spaces are seen
• after 5 months of age, reduced percentages of macrophages and erythroid precursors are seen in bone marrow derived cells
|
|
• increase in the number of apoptotic marcophages in medullary areas of the thymus and in splenic marginal zones
|
|
• enlarged with increased red and white pulp areas
|
|
• dramatic enlargement of the lymphatic follicles compressing and displacing the red pulp to the periphery; however T cell areas are not enlarged
|
|
• 7 days after immunization with a T cell dependent antigen fewer and poorly defined germinal centers develop
|
|
• mild to moderate increase in the number of normoblasts and megakaryocytes and decreased numbers of metachromic macrophages
• after 5 months of age, a 1.5- to 2.5-fold increase in the total number and percentage of B cells is seen correlating with the enlarged white pulp area
|
|
• following intravenous injection with glucan only small scattered granulomas containing mostly macrophages with very few granulocytes are formed
|
|
• increased 2-fold
|
|
• IgG2a is increased 2-fold
|
|
• levels of IgG1, IgG2b, and IgG3 are reduced 3-, 2-, and 4-fold, respectively
|
|
• increased 3-fold
|
|
• T cell levels of GM-CSF and TNFA are increased but levels of IL-2 are similar to wild-type
|
|
• resident peritoneal macrophages produce less NO following stimulation with LPS and TNFG
• basal levels of IL-1b, GM-CSF, TNFA, and IL-6 and LPS and IFNG-stimulated levels of IL-1b and GM-CSF, but not TNFA and IL-6, are reduced in resident peritoneal macrophages
|
|
• a 2-fold reduction in the number of peritoneal macrophages is seen following thioglycollate injection along with this there is a relative increase in the number of polymorphonuclear leukocytes
|
integument
dermatitis
(
J:46911
)
|
• after 5 to 7 months of age, slowly progressing eczematoid skin lesions develop around the nose, ears, eyes, tails, and foreskin
• these lesions are not related to infections and do not compromise survival of mice kept in pathogen free conditions; however in non-pathogen-free environments survival is decreased
|
cellular
|
• a 2-fold reduction in the number of peritoneal macrophages is seen following thioglycollate injection along with this there is a relative increase in the number of polymorphonuclear leukocytes
|
growth/size/body
|
• enlarged with increased red and white pulp areas
|
