Rel^tm1Brv
Targeted Allele Detail

Summary

• Symbol: Rel^tm1Brv
• Name: reticuloendotheliosis oncogene; targeted mutation 1, Rodrigo Bravo
• MGI ID: MGI:3639342
• Synonyms: c-rel^deltaCT
• Gene: Rel Location: Chr11:23686847-23720969 bp, - strand Genetic Position: Chr11, 14.36 cM
• Alliance: Rel^tm1Brv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46911
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A termination codon was introduced at codon 366 followed by a polyadenylation signal and neomycin selection cassette. This was inserted at the beginning of exon 10 such that exon 10, encoding the transcriptional activation domain, was not expressed. Labelling and immunoprecipitation experiments in mutant splenocytes demonstrated that a stable, truncated form of the encoded protein is expressed from this allele. (J:46911)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rel Mutation: 44 strains or lines available

References

• Original: J:46911 Carrasco D, et al., Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein. J Exp Med. 1998 Apr 6;187(7):973-84
• All: 2 reference(s)