Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nme1tm1Jyd mutation
(0 available);
any
Nme1 mutation
(25 available)
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mortality/aging
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• Background Sensitivity: at N10, mortality in litters from homozygous matings in the early postnatal period is 2.2-fold greater than that observed in the F2 mixed background homozygous matings
• Background Sensitivity: at N10, progeny survival is improved with the number of pregnancies the females had experienced, although survival never exceeds 50%
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growth/size/body
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• homozygotes have a significantly lower (20-25%) body weight than controls
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endocrine/exocrine glands
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• in 15-week old virgin mice, ductal branching is poor and the fat pad is not completely filled
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• homozygous or heterozygous pups are not fed by Nme1-deficient females and usually die from dehydration; homozygous pups do have a normal suckling reflex
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integument
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• in 15-week old virgin mice, ductal branching is poor and the fat pad is not completely filled
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• homozygous or heterozygous pups are not fed by Nme1-deficient females and usually die from dehydration; homozygous pups do have a normal suckling reflex
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nme1tm1Jyd mutation
(0 available);
any
Nme1 mutation
(25 available)
|
|
|
mortality/aging
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• Background Sensitivity: at N10, mortality in litters from homozygous matings in the early postnatal period is 1.7-fold greater than that observed in litters from F2 generation homozygotes on the mixed background
• Background Sensitivity: progeny mortality is fixed around 90%
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growth/size/body
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• homozygotes have a significantly lower (20-25%) body weight than controls
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cellular
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• when female nulls are bred to wild-type males, life expectancy of progeny is similar to that when both parents are homozygous for Nme1tm1Jyd; survival of progeny is drastically reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nme1tm1Jyd mutation
(0 available);
any
Nme1 mutation
(25 available)
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|
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mortality/aging
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• F2 homozygotes show a 4-fold increase in mortality in the first 3 days after birth compared to wild-type controls
• Background Sensitivity: in the F6 generation, mortality is 4-fold lower than in the F2 generation; on congenic (N10) backgrounds, mortality is 2x greater than in the F2 mixed background
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growth/size/body
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• F2 pups are significantly smaller (20-25%) than wild-type littermates at birth; this difference is maintained through weaning into adulthood
• Background Sensitivity: weight difference between homozygotes and wild-type disappears after the fourth generation of intercross
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nervous system
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• in an F6 mixed background, Nme1-deficiency appears to affect ex vivo neurofilament organization of peripheral nerve cells
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liver/biliary system
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• on this mixed background, liver regeneration in homozygotes is decreased by 75% in 48 hours in response to removal of the left lateral lobe
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neoplasm
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• 8/10 F2 female mice maintained to 18 months of age developed highly metastatic spontaneous lymphomas compared to 2/7 wild-type controls
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cellular
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• on the F4 mixed background when the female parent is wild-type, life expectancy of heterozygous or wild-type progeny is comparable to that of offspring of wild-type matings; when female nulls are bred to wild-type males, life expectancy of progeny is similar to that when both parents are homozygous for Nme1tm1Jyd
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Analysis Tools