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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Terttm1Rdp
targeted mutation 1, Ronald DePinho
MGI:3628579
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Terttm1Rdp/Terttm1Rdp B6.Cg-Terttm1Rdp MGI:3639938
cn2
 		Ptentm1Rdp/Ptentm1Rdp
Terttm1Rdp/Terttm1Rdp
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:5431943
cn3
 		Ptentm1Rdp/Ptentm1Rdp
Terttm1Rdp/Tert+
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:5431944
cx4
 		Terttm1Rdp/Terttm1Rdp
Trp53tm1Tyj/Trp53+ 		B6.Cg-Trp53tm1Tyj Terttm1Rdp MGI:3639948


Genotype
MGI:3639938
hm1
Allelic
Composition		 Terttm1Rdp/Terttm1Rdp
Genetic
Background		 B6.Cg-Terttm1Rdp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terttm1Rdp mutation (0 available); any Tert mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal chromosome morphology ( J:108914 )
• frequent anaphase bridging in the intestinal crypt cells in late generation homozygous mice
decreased telomere length ( J:108914 )
• successive generational intercrosses yielded mice with progressively shorter telomeres
• the third/fourth generation showed classic cytogenetic and constitutional signs of telomere dysfunction
increased apoptosis ( J:108914 )
• frequent apoptosis and p53 induction in the intestinal crypt cells in late generation homozygous mice

liver/biliary system
decreased liver tumor incidence ( J:108914 )
• marked reduction in the incidence of early neoplastic lesions of hepatocellular carcinoma initiation

reproductive system
testicular atrophy ( J:108914 )
• in late generation homozygous mice
reduced fertility ( J:108914 )
• in late generation homozygous mice
decreased litter size ( J:108914 )
• in late generation homozygous mice

neoplasm
decreased incidence of tumors by chemical induction ( J:108914 )
• reduced incidence of induced hepatocellular carcinoma after CCl4 treatment in late generation (G3/4) homozygous mice compared to early generation (G0) mice
decreased liver tumor incidence ( J:108914 )
• marked reduction in the incidence of early neoplastic lesions of hepatocellular carcinoma initiation

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:108914 )
• reduced incidence of induced hepatocellular carcinoma after CCl4 treatment in late generation (G3/4) homozygous mice compared to early generation (G0) mice

endocrine/exocrine glands
testicular atrophy ( J:108914 )
• in late generation homozygous mice




Genotype
MGI:5431943
cn2
Allelic
Composition		 Ptentm1Rdp/Ptentm1Rdp
Terttm1Rdp/Terttm1Rdp
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rdp mutation (0 available); any Pten mutation (81 available)
Terttm1Rdp mutation (0 available); any Tert mutation (52 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate intraepithelial neoplasia incidence ( J:186105 )
• at generations 3 and 4 (G3/4), all mice develop smaller, poorly progressive tumors compared to G0 mice
• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age
• most tumors fail to progress beyond HPIN by 24 weeks of age unlike in G0 mice
decreased tumor growth/size ( J:186105 )
• smaller, poorly progressive tumors compared to tumors in G0 mice
• markedly increased apoptosis and decreased proliferation in tumor cells compared tumor cells from G0 mice

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:186105 )
• at generations 3 and 4 (G3/4), all mice develop smaller, poorly progressive tumors compared to G0 mice
• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age
• most tumors fail to progress beyond HPIN by 24 weeks of age unlike in G0 mice

cellular
decreased telomere length ( J:186105 )
• reduced at G3/4

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:186105 )
• at generations 3 and 4 (G3/4), all mice develop smaller, poorly progressive tumors compared to G0 mice
• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age
• most tumors fail to progress beyond HPIN by 24 weeks of age unlike in G0 mice




Genotype
MGI:5431944
cn3
Allelic
Composition		 Ptentm1Rdp/Ptentm1Rdp
Terttm1Rdp/Tert+
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rdp mutation (0 available); any Pten mutation (81 available)
Terttm1Rdp mutation (0 available); any Tert mutation (52 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

neoplasm
increased prostate gland adenocarcinoma incidence ( J:186105 )
• all develop rapidly progressive, locally invasive prostate adenocarcinomas
increased prostate intraepithelial neoplasia incidence ( J:186105 )
• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

reproductive system
increased prostate gland adenocarcinoma incidence ( J:186105 )
• all develop rapidly progressive, locally invasive prostate adenocarcinomas
increased prostate intraepithelial neoplasia incidence ( J:186105 )
• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

endocrine/exocrine glands
increased prostate gland adenocarcinoma incidence ( J:186105 )
• all develop rapidly progressive, locally invasive prostate adenocarcinomas
increased prostate intraepithelial neoplasia incidence ( J:186105 )
• high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age




Genotype
MGI:3639948
cx4
Allelic
Composition		 Terttm1Rdp/Terttm1Rdp
Trp53tm1Tyj/Trp53+
Genetic
Background		 B6.Cg-Trp53tm1Tyj Terttm1Rdp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terttm1Rdp mutation (0 available); any Tert mutation (52 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:108914 )
• increased incidence of induced hepatocellular carcinoma after CCl4 treatment in late generation (G3/4) homozygous mice compared to mice with no p53 mutation

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:108914 )
• increased incidence of induced hepatocellular carcinoma after CCl4 treatment in late generation (G3/4) homozygous mice compared to mice with no p53 mutation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory