Phenotypes associated with this allele

• Allele Symbol: Ar^tm1(AR)Dmr
• Allele Name: targeted mutation 1, Diane M Robins
• Allele ID: MGI:3628485
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ar^tm1(AR)Dmr/Y Tg(TRAMP)8247Ng/0	involves: 129S1/Sv * C57BL/6	MGI:3629751
ot2	Ar^tm1(AR)Dmr/Y	involves: 129S1/Sv * C57BL/6J	MGI:3629746

Genotype
MGI:3629751

cx1

• Allelic Composition: Ar^tm1(AR)Dmr/Y; Tg(TRAMP)8247Ng/0
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:108849 )

♂ • at 29 weeks of age, 85% of male transgenic mutant mice had a palpable tumor or had died due to prostate cancer, compared to wild-type transgenic mice; longer Q tract length appears to increase susceptibility to prostate cancer

reproductive system

increased prostate gland tumor incidence ( J:108849 )

♂ • at 29 weeks of age, 85% of male transgenic mutant mice had a palpable tumor or had died due to prostate cancer, compared to wild-type transgenic mice; longer Q tract length appears to increase susceptibility to prostate cancer

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:108849 )

♂ • at 29 weeks of age, 85% of male transgenic mutant mice had a palpable tumor or had died due to prostate cancer, compared to wild-type transgenic mice; longer Q tract length appears to increase susceptibility to prostate cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:108849

Genotype
MGI:3629746

ot2

• Allelic Composition: Ar^tm1(AR)Dmr/Y
• Genetic Background: involves: 129S1/Sv * C57BL/6J

adipose tissue

increased percent body fat/body weight ( J:108849 )

♂ • 24-month old males showed a trend toward higher percentage of body fat compared to wild-type or Ar^tm1(AR)Dmr males

growth/size/body

increased body weight ( J:108849 )

♂ • male mice displayed a trend to higher body weights than male wild-type or Ar^tm1(AR)Dmr