Phenotypes associated with this allele

• Allele Symbol: Nell1^l7R6-6R
• Allele Name: 6 Oak Ridge
• Allele ID: MGI:3626314
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nell1^l7R6-6R/Nell1^l7R6-6R	Not Specified	MGI:3628769

Genotype
MGI:3628769

hm1

• Allelic Composition: Nell1^l7R6-6R/Nell1^l7R6-6R
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:108241 )

• homozygotes do not survive birth and if born by Cesarean section die shortly after birth

respiratory system

enlarged nasal bone ( J:108241 )

respiratory failure ( J:108241 )

• pups born by Cesarean section are unable to breath or open their mouths

skeleton

abnormal axial skeleton morphology ( J:108241 )

• larger and thinner compared to wild-type mice

abnormal neurocranium morphology ( J:108241 )

• decreased ossification and bone density

enlarged frontal bone ( J:108241 )

• larger and thinner compared to wild-type mice

thin frontal bone ( J:108241 )

• larger and thinner compared to wild-type mice

enlarged interparietal bone ( J:108241 )

• larger and thinner compared to wild-type mice

thin interparietal bone ( J:108241 )

• larger and thinner compared to wild-type mice

enlarged parietal bone ( J:108241 )

• larger and thinner compared to wild-type mice

thin parietal bone ( J:108241 )

• larger and thinner compared to wild-type mice

enlarged nasal bone ( J:108241 )

abnormal intervertebral disk morphology ( J:108241 )

• reduction in the intervertebral disk matrix

abnormal spine curvature ( J:108241 )

• pronounced change in spinal curvature is seen at the juncture of the cervical and thoracic vertebrae

abnormal cervical vertebrae morphology ( J:108241 )

• pronounced compression

abnormal vertebrae development ( J:108241 )

• decrease in extracellular matrix surrounding the developing vertebrae and decreased vertebral bone mineralization

abnormal intervertebral disk development ( J:108241 )

• decrease in extracellular matrix surrounding the developing intervertebral disks

decreased bone mineral density ( J:108241 )

• in the skull

abnormal bone mineralization ( J:108241 )

• decreased and irregular pattern of mineralization of the vertebrae, parietal and frontal bones

decreased bone ossification ( J:108241 )

• decreased ossification of the calvarial bones

behavior/neurological

abnormal reflex ( J:108241 )

• newborns display very weak reflexes in the extremities when stimulated by touching

craniofacial

abnormal neurocranium morphology ( J:108241 )

• decreased ossification and bone density

enlarged frontal bone ( J:108241 )

• larger and thinner compared to wild-type mice

thin frontal bone ( J:108241 )

• larger and thinner compared to wild-type mice

enlarged interparietal bone ( J:108241 )

• larger and thinner compared to wild-type mice

thin interparietal bone ( J:108241 )

• larger and thinner compared to wild-type mice

enlarged parietal bone ( J:108241 )

• larger and thinner compared to wild-type mice

thin parietal bone ( J:108241 )

• larger and thinner compared to wild-type mice

enlarged nasal bone ( J:108241 )

growth/size/body

enlarged nasal bone ( J:108241 )

megacephaly ( J:108241 )

• increased head length but not width or height