About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr4lps-2J
defective lipopolysaccharide response 2 Jackson
MGI:3626283
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr4lps-2J/Tlr4lps-2J BXD29-Tlr4lps-2J/J MGI:3629222
ht2
 		Tlr4tm1Aki/Tlr4lps-2J involves: 129P2/OlaHsd * C57BL/6 * DBA/2J MGI:3629223


Genotype
MGI:3629222
hm1
Allelic
Composition		 Tlr4lps-2J/Tlr4lps-2J
Genetic
Background		 BXD29-Tlr4lps-2J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4lps-2J mutation (0 available); any Tlr4 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:107391 )
• in response to inhaled LPS, mice are unresponsive without increases in Tnfa and PMNs like other BXD RI strains




Genotype
MGI:3629223
ht2
Allelic
Composition		 Tlr4tm1Aki/Tlr4lps-2J
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4lps-2J mutation (0 available); any Tlr4 mutation (96 available)
Tlr4tm1Aki mutation (8 available); any Tlr4 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:107391 )
• in response to inhaled LPS, mice respond indistinguishably from Tlr4-deficient mice (no response)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory