Phenotypes associated with this allele

• Allele Symbol: Yy1^tm2Yshi
• Allele Name: targeted mutation 2, Yang Shi
• Allele ID: MGI:3625967
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Yy1^tm2Yshi/Yy1^tm2Yshi	involves: 129S4/SvJae	MGI:3625999
ht2	Yy1^tm1Yshi/Yy1^tm2Yshi	involves: 129S4/SvJae	MGI:3626001

Genotype
MGI:3625999

hm1

• Allelic Composition: Yy1^tm2Yshi/Yy1^tm2Yshi
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:108369 )

• about 26% fewer than expected homozygous pups are found at birth

growth/size/body

decreased birth body size ( J:108369 )

• surviving pups are smaller than wild-type littermates at birth

Genotype
MGI:3626001

ht2

• Allelic Composition: Yy1^tm1Yshi/Yy1^tm2Yshi
• Genetic Background: involves: 129S4/SvJae

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:108369 )

• about 25% of mice die between E13.5 and E14.5 and another 25% die between E16.5 and E19.5

neonatal lethality, complete penetrance ( J:108369 )

• all mice that survive until birth die within 48 hours

respiratory system

respiratory failure ( J:108369 )

• pups isolated at E19.5 fail to inflate their lungs despite visible breathing efforts

cellular

decreased cell proliferation ( J:108369 )

• MEFs proliferate slower and produce smaller colonies

• Cre mediated recombination of the floxed allele produced a decrease in colony number and size and stopped proliferation by blocking cytokinesis

homeostasis/metabolism

cyanosis ( J:108369 )

• live born pups appear cyanotic

integument

pallor ( J:108369 )

• live born pups appear pale