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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map9+
wild type
MGI:3625483
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Map9tm1.2Bcgen/Map9+ involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 MGI:6502658
cn2
 		Map9tm1.1Bcgen/Map9+
Tg(CDX2-cre/ERT2)752Erf/0 		involves: 129S4/SvJaeSor * C57BL/6J * SJL/J MGI:6502656
cx3
 		ApcMin/Apc+
Map9tm1.2Bcgen/Map9+ 		involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J MGI:6502661


Genotype
MGI:6502658
ht1
Allelic
Composition		 Map9tm1.2Bcgen/Map9+
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal centrosome morphology ( J:299895 )
• MEFs show an increase in the percentage of cells with detached centrosomes compared with wild-type MEFs
abnormal pericentriolar material morphology ( J:299895 )
• MEFs show an increase in pericentriolar material fragmentation compared with wild-type MEFs
aneuploidy ( J:299895 )
• a large percentage of mouse embryonic fibroblasts (MEFs) are aneuploid
chromosomal instability ( J:299895 )
• MEFs show elevated rates of lagging chromosomes in anaphase indicating increased chromosomal instability




Genotype
MGI:6502656
cn2
Allelic
Composition		 Map9tm1.1Bcgen/Map9+
Tg(CDX2-cre/ERT2)752Erf/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.1Bcgen mutation (0 available); any Map9 mutation (28 available)
Tg(CDX2-cre/ERT2)752Erf mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal colon morphology ( J:299895 )
• 19% of mice injected with tamoxifen develop colonic dysplasia at 15 months post injection

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:299895 )
• mice treated with colonic carcinogen azoxymethane (AOM) show higher tumor incidence (100%) compared to treated wild-type mice (67%) and have an increase in tumor number and burden compared with controls

neoplasm
increased incidence of tumors by chemical induction ( J:299895 )
• mice treated with colonic carcinogen azoxymethane (AOM) show higher tumor incidence (100%) compared to treated wild-type mice (67%) and have an increase in tumor number and burden compared with controls




Genotype
MGI:6502661
cx3
Allelic
Composition		 ApcMin/Apc+
Map9tm1.2Bcgen/Map9+
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (152 available)
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 2 of 10 mice showing multiple tumors

digestive/alimentary system
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 2 of 10 mice showing multiple tumors




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory