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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgb1tm3Mlkn
targeted mutation 3, Mark L Kahn
MGI:3624806
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itgb1tm3Mlkn/Itgb1tm3Mlkn
Tg(Mx1-cre)1Cgn/0 		involves: 129/Sv * C57BL/6 * CBA MGI:3639582


Genotype
MGI:3639582
cn1
Allelic
Composition		 Itgb1tm3Mlkn/Itgb1tm3Mlkn
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm3Mlkn mutation (0 available); any Itgb1 mutation (59 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating noradrenaline level ( J:108331 )
• after ADP stimulation, platelets fail to bind soluble collagen in an inside-out activation assay
• severely defective platelet adhesion to collagen under flow is observed in mutants in an outside-in activation assay




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory